Results 201 to 210 of about 446,560 (302)

Mapping the substrate landscape of protein phosphatase 2A catalytic subunit PPP2CA

, 2023
Brewer A, Sathe G, Pflug BE, Macartney TJ, Sapkota GP.   +4 more
europepmc   +1 more source

Disease mutations and phosphorylation alter the allosteric pathways involved in autoinhibition of protein phosphatase 2A. [PDF]

J Chem Phys, 2023
Konovalov KA, Wu CG, Qiu Y, Balakrishnan VK, Parihar PS, O'Connor MS, Xing Y, Huang X.   +7 more
europepmc   +1 more source

Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression

Advanced Science, EarlyView.
Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo, Xiaodong Chen, Haojia Wang, Jiying Zhou, Peiying Lu, Jiangying Liu, Keyan Chai, Jingyuan Zhang, Siyun Yang, Shan Lu, Yifei Gao, Zhengsen Jin, Xiaoyu Tao, Zhongdong Hu, Qinglin Li, Jiarui Wu   +15 more
wiley   +1 more source

Retraction: Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair. [PDF]

Oncotarget
Lv P, Wang Y, Ma J, Wang Z, Li JL, Hong CS, Zhuang Z, Zeng YX.   +7 more
europepmc   +1 more source

Long Chain Ceramides Activate Protein Phosphatase-1 and Protein Phosphatase-2A [PDF]

Journal of Biological Chemistry, 1999
Charles E. Chalfant, Katsuya Kishikawa, Marc C. Mumby, Craig Kamibayashi, Alicja Bielawska, Yusuf A. Hannun   +5 more
openaire   +1 more source

Vitamin D Regulates Olfactory Function via Dual Transcriptional and mTOR‐Dependent Translational Control of Synaptic Proteins

Advanced Science, EarlyView.
Vitamin D (VitD) modulates olfactory function by remodeling dendrodendritic synapses in tufted cells through vitamin D receptor‐dependent transcriptional and translational mechanisms. VitD regulates synaptic protein translation partially via mTOR signaling.
Pengcheng Ren, Renhe Cao, Xiaoshan Ye, Wenbin Pang, Qingshang Bi, Meihui Huang, Qionglin Zhou, Dan Ye, Wei Xiang, Le Xiao   +9 more
wiley   +1 more source

Sex-specific regulation of the cardiac transcriptome by the protein phosphatase 2A regulatory subunit B55α. [PDF]

NPJ Metab Health Dis
Sergienko NM, Trewin AJ, Kiriazis H, Raaijmakers AJA, Donner DG, Garside VC, Smith KA, Bell JR, Mellor KM, Delbridge LMD, McMullen JR, Weeks KL.   +11 more
europepmc   +1 more source

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science, EarlyView.
This study identifies Rubicon as a key platelet protein that bidirectionally regulates GPVI and integrin αIIbβ3 signaling. Platelet Rubicon protects against cerebral ischemia‐reperfusion injury by limiting infarction without increasing hemorrhage.
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
wiley   +1 more source

A combination of protein phosphatase 2A inhibition and checkpoint immunotherapy: a perfect storm. [PDF]

Mol Oncol
Clark MC, Lu RO, Ho WS, Dias MH, Bernards R, Forman SJ.   +5 more
europepmc   +1 more source

Protein Phosphatase 2A Inhibitor LB-100 [PDF]

, 2020
openaire   +1 more source