Results 1 to 10 of about 6,418,019 (269)
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy. [PDF]
MedComm (2020), 2022 Protein phosphorylation is an important post‐transcriptional modification involving an extremely wide range of intracellular signaling transduction pathways, making it an important therapeutic target for disease intervention.
Pang K +10 more
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Systematic discovery of biomolecular condensate-specific protein phosphorylation. [PDF]
Nat Chem Biol, 2022 Reversible protein phosphorylation is an important mechanism for regulating (dis)assembly of biomolecular condensates. However, condensate-specific phosphosites remain largely unknown, thereby limiting our understanding of the underlying mechanisms. Here,
Sridharan S +9 more
europepmc +2 more sources
Erythrocyte Protein Phosphorylation
Journal of Biological Chemistry, 1973 Abstract Human erythrocyte membrane protein components have been phosphorylated by an endogenous protein kinase. This transfer of phosphate from [γ-32P]ATP was stimulated by cyclic adenosine 3',5'-monophosphate and inhibited by calcium. The formation of phosphoserine and phosphothreonine bonds and the negligible effect of large changes in sodium and ...
Allen D. Roses, Stanley H. Appel
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Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation [PDF]
Scientific Reports, 2015 AbstractProtein phosphorylation is an important post-translational modification of proteins. Postmortem tissues are widely being utilized in the biomedical studies, but the effects of postmortem on protein phosphorylation have not been received enough attention.
Khalid Iqbal +6 more
openaire +4 more sources
Dissecting the role of protein phosphorylation: a chemical biology toolbox.
Chemical Society Reviews, 2022 Protein phosphorylation is a crucial regulator of protein and cellular function, yet, despite identifying an enormous number of phosphorylation sites, the role of most is still unclear. Each phosphoform, the particular combination of phosphorylations, of
Timothy S. Bilbrough +2 more
semanticscholar +1 more source
Pacritinib abrogates the lupus phenotype in ABIN1[D485N] mice
Lupus Science and Medicine, 2023 Objective The aim of the study was to investigate whether the IRAK1/JAK2/Flt3 inhibitor pacritinib prevents disease development in the lupus-prone ABIN1[D485N] knock-in mouse.Methods ABIN1[D485N] knock-in mice aged 8 weeks were fed for 10 weeks on a diet
Philip Cohen +4 more
doaj +1 more source
PHYTOCHROME and PROTEIN PHOSPHORYLATION [PDF]
Photochemistry and Photobiology, 1990 Abstract— The molecular mode of signal transduction triggered by phytochrome is unknown. One characteristic structural/topographic feature of the physiologically active form (Pfr) of phytochrome is that its tetrapyrrole chromophore becomes preferentially exposed in the Pfr form (compared to the Pr form).
Bal Ram Singh, Pill-Soon Song
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IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes
Nature Communications, 2021 Intraepithelial lymphocytes (IEL) respond to IL-15 complexed with IL-15Ra but how this intrinsically affects IEL is unclear. Here the authors use proteomics analyses of the main mouse IEL subsets and identify PIM kinases as essential for IEL ...
Olivia J. James +7 more
doaj +1 more source
Wellcome Open Research, 2020 Background: Two recessive mutations in the FAM83G gene, causing A34E and R52P amino acid substitutions in the DUF1669 domain of the PAWS1 protein, are associated with palmoplantar keratoderma (PPK) in humans and dogs respectively.
Kevin Z.L. Wu +9 more
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Cell Death Discovery, 2023 Glioblastoma (GBM) is the most common primary brain tumor in adults. Current standard therapy is surgery followed by radiotherapy, with concurrent and adjuvant temozolomide chemotherapy.
Liesbeth Guffens +2 more
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