Results 21 to 30 of about 1,406,847 (366)
HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
doaj +1 more source
An Affinity-directed Protein Missile (AdPROM) System for Targeted Destruction of Endogenous Proteins
Bio-Protocol, 2017 We recently reported an Affinity-directed PROtein Missile (AdPROM) system for the targeted proteolysis of endogenous proteins of interest (POI) (Fulcher et al., 2016 and 2017).
Thomas Macartney +2 more
doaj +1 more source
The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase [PDF]
, 2002 Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation.
Hörth, P. +5 more
core +1 more source
USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]
, 2014 Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Al-Salihi, Mazin A. +11 more
core +3 more sources
The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids
eLife, 2016 The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase).
Gerta Hoxhaj +9 more
doaj +1 more source
eLife, 2021 Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood.
Francois Singh +5 more
doaj +1 more source
The role of serine/threonine phosphatases in human development: Evidence from congenital disorders
Frontiers in Cell and Developmental Biology, 2022 Reversible protein phosphorylation is a fundamental regulation mechanism in eukaryotic cell and organismal physiology, and in human health and disease.
Pieter Vaneynde +5 more
doaj +1 more source
Interplay between R513 methylation and S516 phosphorylation of the cardiac voltage-gated sodium channel [PDF]
, 2014 Arginine methylation is a novel post-translational modification within the voltage-gated ion channel superfamily, including the cardiac sodium channel, Naᵥ1.5.
Beltran-Alvarez, Pedro +5 more
core +2 more sources
Nature Communications, 2021 PKCε is known to exert a role in genome protection by directly phosphorylating and switching the specificity of Aurora B. Here the authors identify SERBP1 as a parallel mitotic PKCε substrate controlling translation and ensuring the integrity of ...
Silvia Martini +11 more
doaj +1 more source
Protein Phosphorylation Goes Negative [PDF]
Molecular Cell, 2009 Analyzing global protein phosphorylation by mass spectrometry remains a challenging task. To this end, Old et al. (2009) recently described a strategy that improves the coverage of phosphorylated sites and employed it to identify B-Raf-dependent phosphorylation sites in melanoma cells.
Pawson, Tony, Taylor, Lorne
openaire +2 more sources