Prevention and partial reversion of the lupus phenotype in ABIN1[D485N] mice by an IRAK4 inhibitor
Lupus Science and Medicine, 2021 Objective We have reported previously that the IRAK4 inhibitor PF06426779 given to ubiquitin-binding-defective ABIN1[D485N] mice at 6 weeks of age prevents the major facets of lupus that develop 10 weeks later.
Philip Cohen +5 more
doaj +1 more source
Phospho.ELM:a database of experimentally verified phosphorylation sites in eukaryotic proteins [PDF]
, 2004 BACKGROUND: Post-translational phosphorylation is one of the most common protein modifications. Phosphoserine, threonine and tyrosine residues play critical roles in the regulation of many cellular processes.
Blom, Nikolaj +8 more
core +4 more sources
Erythrocyte Protein Phosphorylation
Journal of Biological Chemistry, 1973 Abstract Human erythrocyte membrane protein components have been phosphorylated by an endogenous protein kinase. This transfer of phosphate from [γ-32P]ATP was stimulated by cyclic adenosine 3',5'-monophosphate and inhibited by calcium. The formation of phosphoserine and phosphothreonine bonds and the negligible effect of large changes in sodium and ...
A D, Roses, S H, Appel
openaire +2 more sources
PKCɛ switches Aurora B specificity to exit the abscission checkpoint
Nature Communications, 2016 The Aurora B abscission checkpoint is activated when DNA is retained in the cleavage furrow on completion of anaphase. Here the authors show that PKCɛ directly phosphorylates Aurora B triggering a switch in Aurora B substrate specificity to elicit ...
Tanya Pike +4 more
doaj +1 more source
HIF1a-dependent mitophagy facilitates cardiomyoblast differentiation
Cell Stress, 2020 Mitophagy is thought to play a key role in eliminating damaged mitochondria, with diseases such as cancer and neurodegeneration exhibiting defects in this process.
Jin-Feng Zhao +4 more
doaj +1 more source
The role of phosphorylation and dephosphorylation of shell matrix proteins in shell formation : an in vivo and in vitro study [PDF]
, 2018 Protein phosphorylation is a fundamental mechanism regulating many aspects of cellular processes. Shell matrix proteins (SMPs) control crystal nucleation, polymorphism, morphology, and organization of calcium carbonate crystallites during shell formation.
Du, J., Liu, C., Xu, G., Zhang, R.
core +2 more sources
International Journal of Molecular Medicine, 2017 Protein phosphorylation is an important cellular regulatory mechanism as many enzymes and receptors are activated/deactivated by phosphorylation and dephosphorylation events, by means of kinases and phosphatases.
F. Ardito +4 more
semanticscholar +1 more source
An Affinity-directed Protein Missile (AdPROM) System for Targeted Destruction of Endogenous Proteins
Bio-Protocol, 2017 We recently reported an Affinity-directed PROtein Missile (AdPROM) system for the targeted proteolysis of endogenous proteins of interest (POI) (Fulcher et al., 2016 and 2017).
Thomas Macartney +2 more
doaj +1 more source
The chloroplast import receptor Toc34 functions as preprotein-regulated GTPase [PDF]
, 2002 Toc34 is a protein of the chloroplast outer envelope membrane that acts as receptor for preproteins containing a transit sequence. The recognition of preproteins by Toc34 is regulated by GTP binding and phosphorylation.
Hörth, P. +5 more
core +1 more source
DeepPhos: prediction of protein phosphorylation sites with deep learning
Bioinform., 2019 Motivation Phosphorylation is the most studied post-translational modification, which is crucial for multiple biological processes. Recently, many efforts have been taken to develop computational predictors for phosphorylation site prediction, but most ...
Fenglin Luo +4 more
semanticscholar +1 more source