Results 31 to 40 of about 6,418,118 (368)

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids

eLife, 2016
The mechanistic Target of Rapamycin complex 1 (mTORC1) senses intracellular amino acid levels through an intricate machinery, which includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase).
Gerta Hoxhaj, Edward Caddye, Ayaz Najafov, Vanessa P Houde, Catherine Johnson, Kumara Dissanayake, Rachel Toth, David G Campbell, Alan R Prescott, Carol MacKintosh   +9 more
doaj   +1 more source

Pharmacological rescue of impaired mitophagy in Parkinson’s disease-related LRRK2 G2019S knock-in mice

eLife, 2021
Parkinson’s disease (PD) is a major and progressive neurodegenerative disorder, yet the biological mechanisms involved in its aetiology are poorly understood.
Francois Singh, Alan R Prescott, Philippa Rosewell, Graeme Ball, Alastair D Reith, Ian G Ganley   +5 more
doaj   +1 more source

Evolution of protein phosphorylation across 18 fungal species

Science, 2016
Phosphorylation and fungal evolution Phosphorylation after transcription modifies the activity of proteins. To understand how phosphorylation sites have evolved, Studer et al.
R. A. Studer, R. Rodríguez-Mias, Kelsey M. Haas, Joanne I. Hsu, Cristina Viéitez, Carme Solé, D. Swaney, Lindsay B. Stanford, Ivan Liachko, René Böttcher, Maitreya J. Dunham, Eulàlia de Nadal, F. Posas, P. Beltrão, J. Villén   +14 more
semanticscholar   +1 more source

dbPAF: an integrative database of protein phosphorylation in animals and fungi

Scientific Reports, 2016
Protein phosphorylation is one of the most important post-translational modifications (PTMs) and regulates a broad spectrum of biological processes. Recent progresses in phosphoproteomic identifications have generated a flood of phosphorylation sites ...
S. Ullah, Shaofeng Lin, Yang Xu, Wankun Deng, Lili Ma, Ying Zhang, Zexian Liu, Yu Xue   +7 more
semanticscholar   +1 more source

Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

eLife, 2021
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL ...
Alejandro J Brenes, Maud Vandereyken, Olivia J James, Harriet Watt, Jens Hukelmann, Laura Spinelli, Dina Dikovskaya, Angus I Lamond, Mahima Swamy   +8 more
doaj   +1 more source

PTransIPs: Identification of phosphorylation sites enhanced by protein PLM embeddings [PDF]

, 2023
Phosphorylation is pivotal in numerous fundamental cellular processes and plays a significant role in the onset and progression of various diseases. The accurate identification of these phosphorylation sites is crucial for unraveling the molecular mechanisms within cells and during viral infections, potentially leading to the discovery of novel ...
arxiv   +1 more source

Protein phosphorylation and its role in archaeal signal transduction

FEMS Microbiology Reviews, 2016
Reversible protein phosphorylation is the main mechanism of signal transduction that enables cells to rapidly respond to environmental changes by controlling the functional properties of proteins in response to external stimuli.
D. Esser, L. Hoffmann, T. K. Pham, C. Bräsen, Wen Qiu, P. Wright, S. Albers, B. Siebers   +7 more
semanticscholar   +1 more source

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

eLife, 2019
Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors.
Kerryn Berndsen, Pawel Lis, Wondwossen M Yeshaw, Paulina S Wawro, Raja S Nirujogi, Melanie Wightman, Thomas Macartney, Mark Dorward, Axel Knebel, Francesca Tonelli, Suzanne R Pfeffer, Dario R Alessi   +11 more
doaj   +1 more source

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

Nature Communications, 2023
Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear.
Hipólito Nicolás Cuesta-Hernández, Julia Contreras, Pablo Soriano-Maldonado, Jana Sánchez-Wandelmer, Wayland Yeung, Ana Martín-Hurtado, Inés G. Muñoz, Natarajan Kannan, Marta Llimargas, Javier Muñoz, Iván Plaza-Menacho   +10 more
doaj   +1 more source

Role of Protein Phosphorylation in the Regulation of Cell Cycle and DNA-Related Processes in Bacteria

Frontiers in Microbiology, 2016
In all living organisms, the phosphorylation of proteins modulates various aspects of their functionalities. In eukaryotes, protein phosphorylation plays a key role in cell signaling, gene expression, and differentiation.
Transito Garcia-Garcia, S. Poncet, A. Derouiche, Lei Shi, I. Mijakovic, M. Noirot-Gros   +5 more
semanticscholar   +1 more source