Results 41 to 50 of about 7,148,227 (413)

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

eLife, 2019
Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. LRRK2 phosphorylates a subset of Rab GTPases within their Switch-II motif controlling interaction with effectors.
Kerryn Berndsen, Pawel Lis, Wondwossen M Yeshaw, Paulina S Wawro, Raja S Nirujogi, Melanie Wightman, Thomas Macartney, Mark Dorward, Axel Knebel, Francesca Tonelli, Suzanne R Pfeffer, Dario R Alessi   +11 more
doaj   +1 more source

Structural and dynamic determinants for highly selective RET kinase inhibition reveal cryptic druggability

Journal of Advanced Research, 2023
Introduction: The structural and dynamic determinants that confer highly selective RET kinase inhibition are poorly understood. Objectives: To explore the druggability landscape of the RET active site in order to uncover structural and dynamic ...
Moustafa A. Shehata, Julia Contreras, Ana Martín-Hurtado, Aurane Froux, Hossam Taha Mohamed, Ahmed A. El-Sherif, Iván Plaza-Menacho   +6 more
doaj   +1 more source

Complex formation of EphB1/Nck/Caskin1 leads to tyrosine phosphorylation and structural changes of the Caskin1 SH3 domain. [PDF]

, 2012
Scaffold proteins have an important role in the regulation of signal propagation. These proteins do not possess any enzymatic activity but can contribute to the formation of multiprotein complexes.
Balázs Annamária, Buday László, Bőgel Gábor, Fekete Anna, Pesti Szabolcs, Szabó Beáta, Udupa Roopesh   +6 more
core   +2 more sources

Regulation of mitochondrial functions by protein phosphorylation and dephosphorylation

Cell & Bioscience, 2016
The mitochondria are double membrane-bound organelles found in most eukaryotic cells. They generate most of the cell’s energy supply of adenosine triphosphate (ATP).
Sangbin Lim, Kelly R. Smith, S. Lim, R. Tian, Jianrong Lu, M. Tan   +5 more
semanticscholar   +1 more source

An allosteric switch between the activation loop and a c-terminal palindromic phospho-motif controls c-Src function

Nature Communications, 2023
Autophosphorylation controls the transition between discrete functional and conformational states in protein kinases, yet the structural and molecular determinants underlying this fundamental process remain unclear.
Hipólito Nicolás Cuesta-Hernández, Julia Contreras, Pablo Soriano-Maldonado, Jana Sánchez-Wandelmer, Wayland Yeung, Ana Martín-Hurtado, Inés G. Muñoz, Natarajan Kannan, Marta Llimargas, Javier Muñoz, Iván Plaza-Menacho   +10 more
doaj   +1 more source

β-Catenin is a pH sensor with decreased stability at higher intracellular pH. [PDF]

, 2018
β-Catenin functions as an adherens junction protein for cell-cell adhesion and as a signaling protein. β-catenin function is dependent on its stability, which is regulated by protein-protein interactions that stabilize β-catenin or target it for ...
Aberle, Baumgartner, Bree K. Grillo-Hill, Chairoungdua, Choi, Choi, Cold Spring Harbor Protocols, Dai, Daugherty, Denker, Denker, Diane L. Barber, Endo, Forbes, Forbes, Frantz, Frescas, Grillo-Hill, Ha, Hart, Ismahan Chire, Jobelle Peralta, Katharine A. White, Klaus, Krausova, Lee, Li, Liu, Liu, Mario Esquivel, Megy, Morin, Pai, Parks, Peifer, Peifer, Petherick, Pronobis, Reim, Reshkin, Sadot, Sahai-Hernandez, Schönichen, Sedgwick, Shafique, Simons, Stamos, Stehbens, Ulmschneider, Valenta, Vivian N. Bui, Waghmare, Webb, White, White, Wolff, Wu   +56 more
core   +1 more source

Site-specific incorporation of phosphotyrosine using an expanded genetic code. [PDF]

, 2017
Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation.
Allison Wong, Bing Yang, C Fan, C Hoppmann, Christian Hoppmann, CS Tan, DB Johnson, DT Rogerson, H-G Chao, HS Park, J Xie, JJ Ottesen, JK Takimoto, JP Oza, Kevan M Shokat, L Wang, Lei Wang, M Jbara, MK Tarrant, NL Pirman, P Blume-Jensen, PV Hornbeck, R Serwa, R Yau, RA Chong, S George, SG Julien, Shuwei Li, SJ Humphrey, SW Santoro, T Hunter, T Wauer, Tony Hunter, VK Lacey, WA Lim, Z Chen, Z Xiang   +36 more
core   +1 more source

USP45 and Spindly are part of the same complex implicated in cell migration

Scientific Reports, 2018
Ubiquitylation is a protein modification implicated in several cellular processes. This process is reversible by the action of deubiquinating enzymes (DUBs).
Claudia Conte, Eric R. Griffis, Ian Hickson, Ana B. Perez-Oliva   +3 more
doaj   +1 more source

Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes

eLife, 2021
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL ...
Alejandro J Brenes, Maud Vandereyken, Olivia J James, Harriet Watt, Jens Hukelmann, Laura Spinelli, Dina Dikovskaya, Angus I Lamond, Mahima Swamy   +8 more
doaj   +1 more source

dbPAF: an integrative database of protein phosphorylation in animals and fungi

Scientific Reports, 2016
Protein phosphorylation is one of the most important post-translational modifications (PTMs) and regulates a broad spectrum of biological processes. Recent progresses in phosphoproteomic identifications have generated a flood of phosphorylation sites ...
S. Ullah, Shaofeng Lin, Yang Xu, Wankun Deng, Lili Ma, Ying Zhang, Zexian Liu, Yu Xue   +7 more
semanticscholar   +1 more source