Results 101 to 110 of about 562,686 (340)

Identification of precursor transcripts for 6 novel miRNAs expands the diversity on the genomic organisation and expression of miRNA genes in rice [PDF]

, 2008
The plant miRNAs represent an important class of endogenous small RNAs that guide cleavage of an mRNA target or repress its translation to control development and adaptation to stresses.
Bangratz, Martine, Breitler, Jean-Christophe, Brice, Claire, Brugidou, Christophe, Cao, Xiaofeng, Duval, David, Echeverria, Manuel, Guiderdoni, Emmanuel, Hirsch, Judith, Karlowski, Wojciech M., Lacombe, Séverine, Nagasaki, Hiroshi, Panaud, Olivier, Piegu, Benoît, Santi, Carole, Sato, Yutaka   +15 more
core   +1 more source

Processing of mitochondrial precursor proteins.

Biomedica biochimica acta, 1991
The mitochondrial processing enzyme consists of two components, the mitochondrial processing peptidase (MPP) and processing enhancing protein (PEP). MPP and PEP act cooperatively in proteolytic processing of mitochondrial precursor proteins. Most of the mitochondrial precursors possess aminoterminal presequences (also called "targeting sequences" or ...
Arretz, Michael, Schneider, Helmut, Wienhues, Ulla, Neupert, Walter   +3 more
openaire   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Effects of infusing milk precursors into the artery on rumen fermentation in lactating cows

Animal Nutrition, 2016
This experiment was conducted to investigate the effects of infusing milk precursors into the external pudic artery on rumen fermentation in lactating dairy cows.
Xianjue Wang, Changjin Ao, Khas-Erdene, Shuaiwang Liu, Chen Bai, Fuquan Zhang, Ying Zhang, Peng Gao   +7 more
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

MicroRNA-24 regulates vascularity after myocardial infarction [PDF]

, 2011
BACKGROUND: Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying ...
Bauersachs, J., Brand, T., Engelhardt, S., Ertl, G., Fiedler, J., Galuppo, P., Gupta, S. K., Hartmann, D., Heineke, J., Jazbutyte, V., Kirchmaier, B. C., Kneitz, S., Lorenzen, J., Loyer, X., Martin, U., Pena, J., Schulte-Merker, S., Sohn-Lee, C., Soutschek, J., Thum, T., Tuschl, T.   +20 more
core   +3 more sources

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Additivities for Soluble Recombinant Protein Expression in Cytoplasm of Escherichia coli

Fermentation
Recombinant protein expression in Escherichia coli is a fundamental technique in molecular biology and biotechnology. This review provides a comprehensive overview of various additivities to enhance the expression levels of soluble recombinant proteins ...
Denis L. Atroshenko, Egor P. Sergeev, Diana I. Golovina, Anastasia A. Pometun   +3 more
doaj   +1 more source

Discovery of a second SALMFamide gene in the sea urchin Strongylocentrotus purpuratus reveals that L-type and F-type SALMFamide neuropeptides coexist in an echinoderm species [PDF]

, 2010
NOTICE: this is the author’s version of a work that was accepted for publication in MARINE GENOMICS. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may
Bendtsen, Bradbury, Burke, De Bremaeker, De Bremaeker, Díaz-Miranda, Díaz-Miranda, Díaz-Miranda, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Elphick, Ghyoot, Matthew L. Rowe, Maurice R. Elphick, Melarange, Melarange, Mita, Mita, Moore, Moss, Newman, Newman, Ohtani, Pesole, Sodergren, Walker, Yun   +30 more
core   +1 more source