Results 191 to 200 of about 322,759 (220)
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Amyloid precursor protein and mitochondria
Current Opinion in Neurobiology, 2023Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD.
Taylor A. Strope, Heather M. Wilkins
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Sequence of an antifreeze protein precursor
European Journal of Biochemistry, 1984The amino acid sequence of the precursor to the second-most-abundant serum antifreeze protein (B) in the winter flounder has been determined by a combination of protein and DNA sequencing. The precursor is an 82-residue preproprotein which differs in only three positions from the amino acid sequence of the precursor for the most-abundant serum ...
Gary K. Scott +5 more
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Precursors of Embryonic Chick Proteins
Nature, 1956WE wish to report some preliminary findings obtained in the course of a rather extensive investigation into the nature of precursors of embryonic chick proteins (for some recent reviews, see refs. 1 and 2). In these experiments, amino-acids, chicken serum globulin and ovalbumin, labelled in their sulphur amino-acids with sulphur-35, were prepared ...
Harry Walter +2 more
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The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins
Neurodegenerative Diseases, 2006It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte Anliker, Ulrike Müller
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Identification of poliovirus precursor proteins by immunoprecipitation
Virology, 1980Abstract Precursors of poliovirus capsid polypeptides were detected using immunoprecipitation followed by SDS-PAGE. Two common VPO-3-1 precursors were found, and the occurrence of alternative cleavage pathways was confirmed.
Vrijsen, Raphael +2 more
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Early emergence of protein precursors
Advances in Space Research, 1986For the emergence of protein precursors essential to primitive cells three prerequisites must have been fulfilled: selective aqueous polymerization of proteinaceous amino acids from a complex mixture of small organic compounds, selection of homochiral amino acid sequences and catalytic activity with respect, more precisely, to information transfer ...
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Bioinformatic Analysis of Peptide Precursor Proteins
Annals of the New York Academy of Sciences, 2005Abstract: Neuropeptides are among the most important signal molecules in animals. Traditional identification of peptide hormones through peptide purification is a tedious and time‐consuming process. With the advent of the genome sequencing projects, putative peptide precursor can be mined from the genome.
Feng Liu +3 more
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The Mitochondrial Machinery for Import of Precursor Proteins
2007Mitochondria contain a small genome that codes for approx 1% of the total number of proteins that reside in the mitochondria. Hence, most mitochondrial proteins are encoded for by the nuclear genome. After transcription in the nucleus these proteins are synthesized by cytosolic ribosomes.
Kipros Gabriel, Nikolaus Pfanner
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β-Amyloid precursor is a PEST protein
Biochemical and Biophysical Research Communications, 1989The beta-amyloid peptide is generated by proteolytic processing of a family of beta-amyloid precursor proteins. Here we report that beta-amyloid precursor proteins have a primary structure motif known as a PEST sequence, which is predictive of the class of most protease-sensitive rapidly turning over proteins.
Robert Siman, Greg R. Christoph
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