Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson+12 more
wiley +1 more source
The TolC protein of Escherichia coli K12 is synthesised in a precursor form [PDF]
Jim Hackett+2 more
openalex +1 more source
A Universal Biomimetic Approach for Making Artificial Antigen‐Presenting Cells for T Cell Activation
This study shows a biomimetic silica microcapsule (SMC) fabrication method under mild conditions for making artificial antigen‐presenting cells (aAPCs). Inspired by marine biomineralization, peptide‐mediated biosilicification enables silica shell formation on emulsion templates. The resulting SMCs possess a core–shell structure, controlled fluorescence
Fei Hou+5 more
wiley +1 more source
CAV-1 regulates osteocyte communication with osteoclast and osteoblast precursors. [PDF]
Pizarro-Gomez J+7 more
europepmc +1 more source
Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72 [PDF]
Dietmeier, Klaus A.+3 more
core
Transforming Cellulose Into Functional Three‐Dimensional Structures
Cellulose is promising for replacing synthetic polymers due to its excellent mechanical properties and low cost. This review highlights the recent advancements in transforming cellulose into functional 3D structures, including liquid gels and porous materials.
Xia Sun+5 more
wiley +1 more source
The role of NAD<sup>+</sup> metabolism and its modulation of mitochondria in aging and disease. [PDF]
Yusri K+4 more
europepmc +1 more source
Machine Learning Guided Design of Nerve‐On‐A‐Chip Platforms with Promoted Neurite Outgrowth
Compared to labor‐intensive trial‐and‐error experimentation, a machine learning (ML)‐guided workflow, incorporating cell viability assays, data augmentation, ensemble modeling, and model interpretation, is developed to accelerate nerve‐on‐a‐chip optimization and uncover data‐driven design principles.
Tsai‐Chun Chung+8 more
wiley +1 more source
Unifying the analysis of bottom-up proteomics data with CHIMERYS. [PDF]
Frejno M+17 more
europepmc +1 more source