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Lessons from In Utero and Postnatal Exposure to Pesticide DDT: Mechanisms of Chromaffin Cell Vulnerability and Altered Catecholamine Homeostasis. [PDF]
Int J Mol SciYaglova NV +4 more
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Amyloid precursor protein and mitochondria
Current Opinion in Neurobiology, 2023Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD.
Taylor A. Strope, Heather M. Wilkins
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Sequence of an antifreeze protein precursor
European Journal of Biochemistry, 1984The amino acid sequence of the precursor to the second-most-abundant serum antifreeze protein (B) in the winter flounder has been determined by a combination of protein and DNA sequencing. The precursor is an 82-residue preproprotein which differs in only three positions from the amino acid sequence of the precursor for the most-abundant serum ...
M, Pickett +5 more
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Precursors of Embryonic Chick Proteins
Nature, 1956WE wish to report some preliminary findings obtained in the course of a rather extensive investigation into the nature of precursors of embryonic chick proteins (for some recent reviews, see refs. 1 and 2). In these experiments, amino-acids, chicken serum globulin and ovalbumin, labelled in their sulphur amino-acids with sulphur-35, were prepared ...
A, BULBENKO, H R, MAHLER, H, WALTER
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The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins
Neurodegenerative Diseases, 2006It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte, Anliker, Ulrike, Müller
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Amyloid precursor protein in Alzheimer's disease
2023Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity.
Rupesh, Maurya +9 more
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