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Giant Cell Tumor of Bone: Biology, Pathophysiology, and Histopathology in the Era of H3F3A. [PDF]

Biomedicines
Carneiro BD, Brilhante S, Faria CS, Fonseca S, Pozza DH.   +4 more
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Amyloid precursor protein and mitochondria

Current Opinion in Neurobiology, 2023
Amyloid Precursor Protein (APP) processing to amyloid beta (Aβ) is a major hallmark of Alzheimer's disease (AD). The amyloid cascade hypothesis postulates that Aβ accumulation and aggregation causes AD, however many therapeutics targeting Aβ have failed recently. Decades of research describe metabolic deficits in AD.
Taylor A. Strope, Heather M. Wilkins
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Precursors of Embryonic Chick Proteins

Nature, 1956
WE wish to report some preliminary findings obtained in the course of a rather extensive investigation into the nature of precursors of embryonic chick proteins (for some recent reviews, see refs. 1 and 2). In these experiments, amino-acids, chicken serum globulin and ovalbumin, labelled in their sulphur amino-acids with sulphur-35, were prepared ...
A, BULBENKO, H R, MAHLER, H, WALTER
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The Functions of Mammalian Amyloid Precursor Protein and Related Amyloid Precursor-Like Proteins

Neurodegenerative Diseases, 2006
It is well established that proteolytic processing of the β-amyloid precursor protein (APP) generates β-amyloid which plays a central role in the pathogenesis of Alzheimer’s disease. In contrast, the physiological role of APP and the question of whether a loss of these functions contributes to Alzheimer’s disease are still unclear. For a long time, the
Brigitte, Anliker, Ulrike, Müller
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Eukaryotic protein processing: endoproteolysis of precursor proteins

Current Opinion in Biotechnology, 1997
Limited endoproteolysis of biologically inactive polypeptide precursors is a general mechanism generating a diversity of biologically active peptides and proteins in all eukaryotic phyla. One of the major recognition motifs involves cleavage at either specific single or pairs of basic residues of the general formula (R/K) - Xn - (R/K) decreases, where ...
N G, Seidah, M, Chrétien
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Early emergence of protein precursors

Advances in Space Research, 1986
For the emergence of protein precursors essential to primitive cells three prerequisites must have been fulfilled: selective aqueous polymerization of proteinaceous amino acids from a complex mixture of small organic compounds, selection of homochiral amino acid sequences and catalytic activity with respect, more precisely, to information transfer ...
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Bioinformatic Analysis of Peptide Precursor Proteins

Annals of the New York Academy of Sciences, 2005
Abstract: Neuropeptides are among the most important signal molecules in animals. Traditional identification of peptide hormones through peptide purification is a tedious and time‐consuming process. With the advent of the genome sequencing projects, putative peptide precursor can be mined from the genome.
G, Baggerman, F, Liu, G, Wets, L, Schoofs   +3 more
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