Results 261 to 270 of about 3,910,498 (310)

Early emergence of protein precursors

Advances in Space Research, 1986
For the emergence of protein precursors essential to primitive cells three prerequisites must have been fulfilled: selective aqueous polymerization of proteinaceous amino acids from a complex mixture of small organic compounds, selection of homochiral amino acid sequences and catalytic activity with respect, more precisely, to information transfer ...
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Eukaryotic protein processing: endoproteolysis of precursor proteins

Current Opinion in Biotechnology, 1997
Limited endoproteolysis of biologically inactive polypeptide precursors is a general mechanism generating a diversity of biologically active peptides and proteins in all eukaryotic phyla. One of the major recognition motifs involves cleavage at either specific single or pairs of basic residues of the general formula (R/K) - Xn - (R/K) decreases, where ...
N G, Seidah, M, Chrétien
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Amyloid Precursor Protein Is Found in Lysosomes

Gerontology, 2009
The major component of Alzheimer’s disease amyloid is a small polypeptide referred as the amyloid β protein, which is derived from a larger precursor, amyloid precursor protein (APP). Cell fractionation and immunological studies on the APP molecule indicate that APP is localized either in the neuron and astrocyte and that the molecule is recovered from
K, Tagawa, M, Yazaki, T, Kinouchi, K, Maruyama, H, Sorimachi, T, Tsuchiya, K, Suzuki, S, Ishiura   +7 more
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Bioinformatic Analysis of Peptide Precursor Proteins

Annals of the New York Academy of Sciences, 2005
Abstract: Neuropeptides are among the most important signal molecules in animals. Traditional identification of peptide hormones through peptide purification is a tedious and time‐consuming process. With the advent of the genome sequencing projects, putative peptide precursor can be mined from the genome.
G, Baggerman, F, Liu, G, Wets, L, Schoofs   +3 more
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Function of amyloid and amyloid protein precursor

Clinical Neurology and Neurosurgery, 1992
A short review is given of the functions of amyloid (beta/A4) and its precursor protein (APP). The possible relationship between amyloid deposition and dementia is discussed.
R A, Roos, J, Haan
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Amyloid beta protein precursor is a mitogen

Biochemical and Biophysical Research Communications, 1989
The form of the secreted amyloid beta-protein precursor which contains the protease inhibitor sequence is mitogenic for Swiss 3T3 cells, while the precursor molecule lacking the protease inhibitor domain is not. A ten-fold stimulation of DNA synthesis occurs at 8 x 10(-9) M protein.
D, Schubert, G, Cole, T, Saitoh, T, Oltersdorf   +3 more
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β-Amyloid precursor is a PEST protein

Biochemical and Biophysical Research Communications, 1989
The beta-amyloid peptide is generated by proteolytic processing of a family of beta-amyloid precursor proteins. Here we report that beta-amyloid precursor proteins have a primary structure motif known as a PEST sequence, which is predictive of the class of most protease-sensitive rapidly turning over proteins.
R, Siman, G, Christoph
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Neurite outgrowth and the amyloid protein precursor

Neurobiology of Aging, 1989
Neurite outgrowth in Alzheimer's disease may well be a multifactorial phenomenon. Recent evidence suggests possible roles for the protease inhibitor domain of the 751 amino acid amyloid precursor protein (APP), as well as for the 695 amino acid APP.
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Identification of poliovirus precursor proteins by immunoprecipitation

Virology, 1980
Abstract Precursors of poliovirus capsid polypeptides were detected using immunoprecipitation followed by SDS-PAGE. Two common VPO-3-1 precursors were found, and the occurrence of alternative cleavage pathways was confirmed.
Vrijsen, Raphael, Brioen, Paul, Boeye, Albert   +2 more
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Processing of precursor proteins by plant mitochondria

Archives of Biochemistry and Biophysics, 1990
Precursor proteins from Neurospora crassa were correctly processed by a matrix extract from Vicia faba and cauliflower mitochondria. Processing yielded mature protein of the same molecular mass as mature Neurospora protein. The processing activity has two components.
J, Whelan, P, O'Mahony, M A, Harmey
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