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Sequence of an antifreeze protein precursor
European Journal of Biochemistry, 1984The amino acid sequence of the precursor to the second-most-abundant serum antifreeze protein (B) in the winter flounder has been determined by a combination of protein and DNA sequencing. The precursor is an 82-residue preproprotein which differs in only three positions from the amino acid sequence of the precursor for the most-abundant serum ...
M, Pickett +5 more
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Amyloid precursor protein in Alzheimer's disease
2023Amyloid precursor protein (APP) is a membrane protein expressed in several tissues. The occurrence of APP is predominant in synapses of nerve cells. It acts as a cell surface receptor and plays a vital role as a regulator of synapse formation, iron export and neural plasticity.
Rupesh, Maurya +9 more
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Precursor keratin protein from human epidermis
British Journal of Dermatology, 1978Prekeratin has been isolated from human epidermis using the method of Matoltsy for bovine nose epidermis. Analysis by sedimentation equilibrium indicates that human prekeratin is heterogeneous in solution. The molecular weight range is from about 200 X 10(3) to at least 2 X 10(6).
J, Baynes +3 more
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Processing of pro-hormone precursor proteins
Archives of Biochemistry and Biophysics, 1989Peptide-hormones and other biologically active peptides are synthesized as higher molecular weight precursor proteins (pro-proteins) which must undergo post-translational modification to yield the bioactive peptide(s). These post-translational enzymatic events include limited endoproteolysis and may include other modifications of the generated peptide ...
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Regulation of Amyloid Precursor Protein Cleavage
Journal of Neurochemistry, 1999Abstract : Multiple lines of evidence suggest that increased production and/or deposition of the β‐amyloid peptide, derived from the amyloid precursor protein, contributes to Alzheimer's disease. A growing list of neuro‐transmitters, growth factors, cytokines, and hormones have been shown to regulate amyloid precursor protein processing.
J, Mills, P B, Reiner
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Identification of microRNA Precursor-Associated Proteins
2018MicroRNA (miRNA) biogenesis is regulated intricately at multiple levels. In addition to transcriptional control of pri-miRNA loci, sequence as well as structural features of the pri-miRNA-stem loop determine its processing efficiency by the endonucleases Drosha and Dicer.
Thomas, Treiber +2 more
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Mitochondrial import: properties of precursor proteins
Biochemistry and Cell Biology, 1990Most mitochondrial proteins are synthesized in the cytoplasm as higher molecular weight precursors and must cross at least one membrane to reach their final destination. Amino-terminal extensions of the precursors, termed signal peptides, have been shown to contain the necessary targeting information. Although no consensus sequence has been determined
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