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The Functions of the Amyloid Precursor Protein Gene
Reviews in the Neurosciences, 2001The amyloid precursor protein (APP) gene and its protein products have multiple functions in the central nervous system and fulfil criteria as neuractive peptides: presence, release and identity of action. There is increased understanding of the role of secretases (proteases) in the metabolism of APP and the production of its peptide fragments. The APP
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Identification of microRNA Precursor-Associated Proteins
2018MicroRNA (miRNA) biogenesis is regulated intricately at multiple levels. In addition to transcriptional control of pri-miRNA loci, sequence as well as structural features of the pri-miRNA-stem loop determine its processing efficiency by the endonucleases Drosha and Dicer.
Thomas, Treiber +2 more
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The Mitochondrial Machinery for Import of Precursor Proteins
2007Mitochondria contain a small genome that codes for approx 1% of the total number of proteins that reside in the mitochondria. Hence, most mitochondrial proteins are encoded for by the nuclear genome. After transcription in the nucleus these proteins are synthesized by cytosolic ribosomes.
Kipros, Gabriel, Nikolaus, Pfanner
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Processing of pro-hormone precursor proteins
Archives of Biochemistry and Biophysics, 1989Peptide-hormones and other biologically active peptides are synthesized as higher molecular weight precursor proteins (pro-proteins) which must undergo post-translational modification to yield the bioactive peptide(s). These post-translational enzymatic events include limited endoproteolysis and may include other modifications of the generated peptide ...
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Genetics of the Alzheimer Amyloid Protein Precursor
1990Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by gradual loss of memory, reasoning, orientation, and judgment (Katzman, 1983). AD generally occurs as a sporadic disorder of unknown cause. However, a proportion of cases, which have been termed familial Alzheimer’s disease (FAD), are caused by a genetic defect that is
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Protein as a Carbohydrate Precursor in the Chick
The Journal of Nutrition, 1967R, Renner, A M, Elcombe
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Processing of precursors of mitochondrial proteins
Biochemical Society Transactions, 1984B, Schmidt, W, Neupert
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