Results 61 to 70 of about 3,910,498 (310)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin [PDF]

, 1996
The cornified envelope is a layer of transglutaminase cross-linked protein that is deposited under the plasma membrane of keratinocytes in the outermost layers of the epidermis.
Dooley, TP, Hajibagheri, MAN, Watt, FM, M A Hajibagheri, Ruhrberg, C, Simon, M, F M Watt, C Ruhrberg, M Simon, T P Dooley   +9 more
core   +1 more source

In silico Study of Bioactivity and Potential of Small Molecules from Manalagi Apple (Malus sylvestris L. Mill.) as Inhibitors of Trimethylamine-N-Oxide (TMAO) Precursors

Journal of Pure and Applied Chemistry Research
Targeting the precursors of trimethylamine-N-oxide(TMAO), such as choline, betaine, and enzymes produced by the FMO3 gene, through natural compounds may reduce risk factors such as cardiovascular and metabolic diseases.
Karimatul Himmah, Putri Elok Septiana Dewi, Setiya Purbasari, Mufidatur Rosyidah, Tiwuk Susantiningsih   +4 more
doaj   +1 more source

Lactic acid promotes metastatic niche formation in bone metastasis of colorectal cancer

Cell Communication and Signaling, 2021
Background To investigate the effect of lactic acid (LA) on the progression of bone metastasis from colorectal cancer (CRC) and its regulatory effects on primary CD115 (+) osteoclast (OC) precursors.
Jin Qian, Zi-chen Gong, Yi-na Zhang, Hong-hua Wu, Jing Zhao, Li-ting Wang, Li-juan Ye, Da Liu, Wei Wang, Xia Kang, Jun Sheng, Wei Xu, Xi-lin Liu, Juan Wu, Wei Zheng   +14 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Evidence that dengue virus envelope protein in patient platelets originates from infection of megakaryocytic precursors.

PLoS ONE
Dengue virus infection is a major global health problem with clinical outcomes ranging from mild febrile illness to severe disease. Although a reduction in platelet counts is a common feature of dengue, the mechanisms underlying the presence of viral ...
Marcos Alvarado Silva, Tannya Karen Castro Jimenez, Edwin Antonio Lopez Kelly, Nallely Diaz Lima, José Alberto San Juan Luis, Diego Sait Cruz Hernández, Sergio Roberto Aguilar Ruiz, José Bustos Arriaga   +7 more
doaj   +1 more source

ELECTROPHORETIC SYSTEMS FOR PREPARATIVE FRACTIONATION OF PROTEIN PRECURSORS OF BIOACTIVE PEPTIDES FROM COW’S MILK

Harčova Nauka ì Tehnologìâ, 2018
The article considers the possibility of obtaining purified fractions-precursors of bioactive peptides from milk proteins by the method of preparative electrophoresis.
V. Yukalo, L. Storozh, K. Datsyshy, O. Krupa   +3 more
doaj   +1 more source

Smooth muscle protein 22α-Cre recombination in resting cardiac fibroblasts and hematopoietic precursors

Scientific Reports, 2022
The Cre-loxP system has been widely used for cell- or organ-specific gene manipulation, but it is important to precisely understand what kind of cells the recombination takes place in.
Shinya Ikeda, Sachiko Sugioka, Takeshi Kimura, Noboru Ashida   +3 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery

Stem Cell Reports, 2017
Summary: Epigenetic modifications have emerged as attractive molecular substrates that integrate extrinsic changes into the determination of cell identity.
Ayden Gouveia, Matthew Seegobin, Timal S. Kannangara, Ling He, Fredric Wondisford, Cesar H. Comin, Luciano da F. Costa, Jean-Claude Béïque, Diane C. Lagace, Baptiste Lacoste, Jing Wang   +10 more
doaj   +1 more source