Results 61 to 70 of about 356,376 (266)

Thioesterases in fruit and the generation of high impact aroma chemicals [PDF]

, 2008
Volatile organosulphur compounds (VOSCs) are key ingredients in the aroma of tropical fruit where they are active as both free thiols and the respective thioesters.
Tapp, Edward
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Proteomic and 3D structure analyses highlight the C/D box snoRNP assembly mechanism and its control [PDF]

, 2014
In vitro, assembly of box C/D small nucleolar ribonucleoproteins (snoRNPs) involves the sequential recruitment of core proteins to snoRNAs. In vivo, however, assembly factors are required (NUFIP, BCD1, and the HSP90–R2TP complex), and it is unknown ...
Franck Vandermoere, Ahmad, Yasmeen, Bertrand, Edouard, Bérengère Pradet-Balade, Leonhardt, Heinrich, Charron, Christophe, Hallais, Marie, Christophe Charron, Marie Hallais, Vandermoere, Franck, Jonathan Bizarro, Pradet-Balade, Berengere, Christiane Branlant, Yasmeen Ahmad, Chagot, Marie-Eve, Céline Verheggen, Lamond, Angus; id_orcid, Heinrich Leonhardt, Branlant, Christiane, Edouard Bertrand, Lamond, Angus, Charpentier, Bruno, Angus Lamond, Xavier Manival, Manival, Xavier, Marie-Eve Chagot, Westman, Belinda, Boulon, Severine, Belinda Westman, Séverine Boulon, Verheggen, Celine, Bruno Charpentier, Bizarro, Jonathan   +32 more
core   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

The Precursor of the α-Fibrous Protein of Epidermis

Journal of Investigative Dermatology, 1971
Extraction of cow snout epidermis with citrate buffer pH 2.65 yields an α-fibrous protein (prekeratin) which can be purified by precipitation at pH 7.0, pH 6.0, pH 5.0 and pH 4.5. A precursor pool of α-fibrous protein has been identified in the microsomal fraction of homogenized tissue and this protein is also soluble in acid buffers at pH 2.65 and ...
Baden, Howard P., Gifford, Ann M., Goldsmith, Lowell A.   +2 more
openaire   +2 more sources

Cytosolic Quality Control of Mitochondrial Protein Precursors-The Early Stages of the Organelle Biogenesis. [PDF]

Int J Mol Sci, 2021
Lenkiewicz AM, Krakowczyk M, Bragoszewski P.   +2 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

The neuroendocrine polypeptide 7B2 is a precursor protein.

Journal of Biological Chemistry, 1990
The neuroendocrine protein 7B2 is highly conserved and widely present in neurons and endocrine cells. It is coexpressed with the prohormone proopiomelanocortin (POMC) in the intermediate lobe of the pituitary gland of Xenopus laevis. To study the biosynthesis of 7B2 in this amphibian, an anti-7B2 monoclonal antibody was used in immunoprecipitation ...
Ayoubi, T.A., van Duijnhoven, H.L., van de Ven, W.J., Jenks, B.G., Jenks, B.G., Roubos, E.W., Martens, G.J.M.   +6 more
openaire   +3 more sources