Results 41 to 50 of about 579,499 (312)

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

Nature Communications, 2018
The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane.
Alexander Benjamin Schendzielorz, Piotr Bragoszewski, Nataliia Naumenko, Ridhima Gomkale, Christian Schulz, Bernard Guiard, Agnieszka Chacinska, Peter Rehling   +7 more
doaj   +1 more source

Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.

PLoS ONE, 2021
In yeast and human cells many of the ribosomal proteins (r-proteins) are required for the stabilisation and productive processing of rRNA precursors. Functional coupling of r-protein assembly with the stabilisation and maturation of subunit precursors ...
Gisela Pöll, Michael Pilsl, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit   +4 more
doaj   +1 more source

Amyloid precursor protein induces reactive astrogliosis

Acta Physiologica, 2023
AbstractAimAstrocytes respond to stressors by acquiring a reactive state characterized by changes in their morphology and function. Molecules underlying reactive astrogliosis, however, remain largely unknown. Given that several studies observed increase in the Amyloid Precursor Protein (APP) in reactive astrocytes, we here test whether APP plays a role
Gretsen Velezmoro Jauregui, Dragana Vukić, Isaac G. Onyango, Carlos Arias, Jan S. Novotný, Kateřina Texlová, Shanshan Wang, Kristina Locker Kovačovicova, Natalie Polakova, Jana Zelinkova, Maria Čarna, Valentina Lacovich Strašil, Brian P. Head, Daniel Havas, Martin Mistrik, Robert Zorec, Alexei Verkhratsky, Liam Keegan, Mary O’Connel, Robert Rissman, Gorazd B. Stokin   +20 more
openaire   +6 more sources

Mitochondrial molecular chaperones [PDF]

, 1994
After synthesis in the cytosol, most mitochondrial proteins must traverse mitochondrial membranes to reach their functional location. During this process, proteins become unfolded and then refold to attain their native conformation after crossing the ...
Atencio, Caplan, Caplan, Cheng, Craig, Cyr, Deshales, Eilers, Gambill, Glick, Glick, Hartl, Hartl, Hwang, Johnson, Kang, Kiebler, Langer, Liberek, Manning-Krieg, Neupert, Ostermann, Palleros, Rassow, Rospert, Sanders, Scherer, Schleyer, Schröder, Simon, Vestweber, Voos, Xia   +32 more
core   +1 more source

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider, Amelie Alfert, Marc Hotfilder, Birgit Burkardt, Marcel te Vrugt   +4 more
wiley   +1 more source

Tracking the Subcellular Localization of Surface Proteins in Staphylococcus aureus by Immunofluorescence Microscopy

Bio-Protocol, 2021
Surface proteins of Staphylococcus aureus and other Gram-positive bacteria play essential roles in bacterial colonization and host-microbe interactions. Surface protein precursors containing a YSIRK/GXXS signal peptide are translocated across the septal ...
Salvatore Scaffidi, Mac Shebes, Wenqi Yu
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Identification of General and Heart-Specific miRNAs in Sheep (Ovis aries).

PLoS ONE, 2015
MicroRNAs (miRNAs or miRs) are small regulatory RNAs crucial for modulation of signaling pathways in multiple organs. While the link between miRNAs and heart disease has grown more readily apparent over the past three years, these data are primarily ...
Alessandro Laganà, Dario Veneziano, Tyler Spata, Richard Tang, Hua Zhu, Peter J Mohler, Ahmet Kilic   +6 more
doaj   +1 more source

Elovanoids downregulate SARS-CoV-2 cell-entry, canonical mediators and enhance protective signaling in human alveolar cells

Scientific Reports, 2021
The pro-homeostatic lipid mediators elovanoids (ELVs) attenuate cell binding and entrance of the SARS-CoV-2 receptor-binding domain (RBD) as well as of the SARS-CoV-2 virus in human primary alveoli cells in culture.
Jorgelina M. Calandria, Surjyadipta Bhattacharjee, Nicholas J. Maness, Marie-Audrey I. Kautzmann, Aram Asatryan, William C. Gordon, Khanh V. Do, Bokkyoo Jun, Pranab K. Mukherjee, Nicos A. Petasis, Nicolas G. Bazan   +10 more
doaj   +1 more source

Amyloid Precursor Protein and Alzheimer’s Disease

International Journal of Molecular Sciences, 2023
Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau ...
Kseniia S. Orobets, Andrey L. Karamyshev
openaire   +2 more sources