Results 31 to 40 of about 344,855 (265)

Congenital Dyserythropoietic Anemia Type II: molecular analysis and expression of the SEC23B Gene

Orphanet Journal of Rare Diseases, 2011
Background Congenital dyserythropoietic anemia type II (CDAII), the most common form of CDA, is an autosomal recessive condition. CDAII diagnosis is based on invasive, expensive, and time consuming tests that are available only in specialized ...
Punzo Francesca, Bertoli-Avella Aida M, Scianguetta Saverio, Della Ragione Fulvio, Casale Maddalena, Ronzoni Luisa, Cappellini Maria D, Forni Gianluca, Oostra Ben A, Perrotta Silverio   +9 more
doaj   +1 more source

Targeting apoptotic anticancer response with natural glucosinolates from cell suspension culture of Lepidium sativum

Journal of Genetic Engineering and Biotechnology, 2023
Background Finding natural products with anticancer activity is an effective strategy to fight this disease. In this respect, Lepidium sativum or garden cress (family Brassicaceae) has been widely used worldwide for its wide therapeutic application ...
Mona M. Ibrahim, Marwa M. Mounier, Shawky A. Bekheet   +2 more
doaj   +1 more source

Amyloid Precursor Protein and Alzheimer’s Disease

International Journal of Molecular Sciences, 2023
Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau ...
Kseniia S. Orobets, Andrey L. Karamyshev
openaire   +2 more sources

Amyloid Precursor-like Protein 1 Influences Endocytosis and Proteolytic Processing of the Amyloid Precursor Protein [PDF]

Journal of Biological Chemistry, 2006
Ectodomain shedding of the amyloid precursor protein (APP) is a key regulatory step in the generation of the Alzheimer disease amyloid beta peptide (Abeta). The molecular mechanisms underlying the control of APP shedding remain little understood but are in part dependent on the low density lipoprotein receptor-related protein (LRP), which is involved ...
Neumann, Stephanie, Schöbel, Susanne, Jäger, Sebastian, Trautwein, Anna, Haass, Christian, Pietrzik, Claus U., Lichtenthaler, Stefan F.   +6 more
openaire   +3 more sources

Citrus psorosis virus 24K protein inhibits the processing of miRNA precursors by interacting with components of the biogenesis machinery

Microbiology Spectrum
Sweet orange (Citrus sinensis) is one of the most important fruit crops worldwide. Virus infections in this crop can interfere with cellular processes, causing dramatic economic losses. By performing RT-qPCR analyses, we demonstrated that citrus psorosis
Facundo E. Marmisolle, María B. Borniego, Damián A. Cambiagno, Lucia Gonzalo, María L. García, Pablo A. Manavella, Carmen Hernández, Carina A. Reyes   +7 more
doaj   +1 more source

Proteasomal degradation competes with Mia40-mediated import into mitochondria

BMC Biology, 2018
Tandem fluorescent protein timers are elegant tools to determine proteolytic stabilities of cytosolic proteins with high spatial and temporal resolution. In a new study published in BMC Biology, Kowalski et al.
Eva Zöller, R. Todd Alexander, Johannes M. Herrmann   +2 more
doaj   +1 more source

Effects of Chickpea Protein on Carbohydrate Reactivity in Acrylamide Formation in Low Humidity Model Systems

Foods, 2020
Asparagine and reducing sugars are the principal precursors of acrylamide in foods. Their main sources in pastries are flour and hen egg yolks. One method of reducing acrylamide content in food may be to add a chickpea protein preparation. The aim of the
Karolina Miśkiewicz, Justyna Rosicka-Kaczmarek, Ewa Nebesny   +2 more
doaj   +1 more source

Protocol for assessing the clogging of the mitochondrial translocase of the outer membrane by precursor proteins in human cells

STAR Protocols
Summary: Protein import into the mitochondria is required for organellar function. Inefficient import can result in the stalling of mitochondrial precursors inside the translocase of the outer membrane (TOM) and blockage of the mitochondrial entry gate ...
John Kim, Hilla Weidberg
doaj   +1 more source

Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

Nature Communications, 2018
The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane.
Alexander Benjamin Schendzielorz, Piotr Bragoszewski, Nataliia Naumenko, Ridhima Gomkale, Christian Schulz, Bernard Guiard, Agnieszka Chacinska, Peter Rehling   +7 more
doaj   +1 more source

Analysis of subunit folding contribution of three yeast large ribosomal subunit proteins required for stabilisation and processing of intermediate nuclear rRNA precursors.

PLoS ONE, 2021
In yeast and human cells many of the ribosomal proteins (r-proteins) are required for the stabilisation and productive processing of rRNA precursors. Functional coupling of r-protein assembly with the stabilisation and maturation of subunit precursors ...
Gisela Pöll, Michael Pilsl, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit   +4 more
doaj   +1 more source