The protein import apparatus of chloroplasts [PDF]
, 1993 Routing of cytosolically synthesized precursor proteins into chloroplasts is a specific process which involves a multitude of soluble and membrane components.
Soll, Jürgen +3 more
core +1 more source
Successive translocation into and out of the mitochondrial matrix [PDF]
, 1987 We investigated the import and sorting pathways of cytochrome b2 and cytochrome c1, which are functionally located in the intermembrane space of mitochondria.
Ostermann, Joachim +3 more
core +1 more source
Amyloid Precursor Protein and Alzheimer’s Disease
International Journal of Molecular Sciences, 2023 Alzheimer’s disease (AD) is one of the most common neurodegenerative disorders associated with age or inherited mutations. It is characterized by severe dementia in the late stages that affect memory, cognitive functions, and daily life overall. AD progression is linked to the accumulation of cytotoxic amyloid beta (Aβ) and hyperphosphorylated tau ...
Kseniia S. Orobets, Andrey L. Karamyshev
openaire +2 more sources
Early emergence of ethnic differences in type 2 diabetes precursors in the UK: the Child Heart and Health Study in England (CHASE Study) [PDF]
, 2010 <p><b>Background:</b> Adults of South Asian origin living in the United Kingdom have high risks of type 2 diabetes and central obesity; raised circulating insulin, triglyceride, and C-reactive protein concentrations; and low HDL ...
Cook Derek G. +39 more
core +1 more source
MOM19, an import receptor for mitochondrial precursor proteins [PDF]
, 1989 We have identified a 19 kd protein of the mitochondrial outer membrane (MOM19). Monospecific IgG and Fab fragments directed against MOM19 inhibit import of precursor proteins destined for the various mitochondrial subcompartments, including porin ...
Söllner, Thomas +4 more
core +1 more source
Characterization of the protein import apparatus in isolated outer envelopes of chloroplasts [PDF]
, 1991 Isolated outer envelope membrane from pea (Pisum sativum L.) chloroplasts can be used in vitro to study binding and partial translocation of precursor proteins destined for the inside of the organelle.
Soll, Jürgen, Waegemann, Karin
core +1 more source
A mechanism of protein localization : the signal hypothesis and bacteria [PDF]
, 1980 We are studying the molecular mechanism of cellular protein localization. The availability of genetic techniques, such as gene fusion in Escherichia coli, has made this problem particularly amenable to study in this prokaryote.
Hall, M. N. +5 more
core +1 more source
Mitochondrial protein import [PDF]
, 1988 Transport of nuclear-encoded precursor proteins into mitochondria includes proteolytic cleavage of aminoterminal targeting sequences in the mitochondrial matrix. We have isolated the processing activity from Neurospora crassa.
Hawlitschek, Gerhard +5 more
core +1 more source
Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin [PDF]
, 1996 The cornified envelope is a layer of transglutaminase cross-linked protein that is deposited under the plasma membrane of keratinocytes in the outermost layers of the epidermis.
Dooley, TP +9 more
core +1 more source
Computational Design and Experimental Characterization of Protein Oligomers [PDF]
, 2004 Previous efforts in designing protein binding interfaces have focused on altering binding specificities. These methods fall short, however, when applied to the design of novel binding sites due to difficulties in accurately modeling protein backbones ...
Huang, Po-Ssu
core +1 more source