Results 11 to 20 of about 3,910,498 (310)

Protein folding causes an arrest of preprotein translocation into mitochondria in vivo [PDF]

, 1991
With vital yeast cells, a hybrid protein consisting of the amino- terminal third of the precursor to cytochrome b2 and of the entire dihydrofolate reductase was arrested on the import pathway into mitochondria.
Tropschug, Maximilian, Pfanner, Nikolaus, Becker, Karin, Schleyer, Manfred, Neupert, Walter, Horwich, Arthur, Guiard, Bernard, Wienhues, Ulla   +7 more
core   +2 more sources

Mitochondrial Protein Import [PDF]

, 1987
The role of nucleoside triphosphates (NTPs) in mitochondrial protein import was investigated with the precursors of N. crassa ADP/ATP carrier, F1-ATPase subunit β, F0-ATPase subunit 9, and fusion proteins between subunit 9 and mouse dihydrofolate ...
Pfanner, Nikolaus, Tropschug, Maximilian, Neupert, Walter   +2 more
core   +1 more source

Amyloid precursor protein and amyloid precursor-like protein 2 in cancer

Oncotarget, 2016
Amyloid precursor protein (APP) and its family members amyloid precursor-like protein 1 (APLP1) and amyloid precursor-like protein 2 (APLP2) are type 1 transmembrane glycoproteins that are highly conserved across species. The transcriptional regulation of APP and APLP2 is similar but not identical, and the cleavage of both proteins is regulated by ...
Pandey, Poomy, Sliker, Bailee, Peters, Haley L., Tuli, Amit, Herskovitz, Jonathan, Smits, Kaitlin, Purohit, Abhilasha, Singh, Rakesh K., Dong, Jixin, Batra, Surinder K., Coulter, Donald W., Solheim, Joyce C.   +11 more
openaire   +3 more sources

Early steps in mitochondrial protein import [PDF]

, 1990
The process of insertion of precursor proteins into mitochondrial membranes was investigated using a hybrid protein (pSc1-c) that contains dual targeting information and, at the same time, membrane insertion activity.
Stuart, Rosemary A., Neupert, Walter, Nicholson, Donald W.   +2 more
core   +1 more source

Computer-aided characteristics of proteins as potential precursors of bioactive peptides

Polimery, 2003
Proteins, apart from their basic functions, may play the role of precursors of the peptides that regulate the body functions and/or show anti­hypertensive, antithrombotic, antiamnestic, immunomodulating and other activities. Computer analysis of 109
Jerzy Dziuba
doaj   +1 more source

ENTAIL: yEt aNoTher amyloid fIbrils cLassifier

BMC Bioinformatics, 2022
Background This research aims to increase our knowledge of amyloidoses. These disorders cause incorrect protein folding, affecting protein functionality (on structure).
Alessia Auriemma Citarella, Luigi Di Biasi, Fabiola De Marco, Genoveffa Tortora   +3 more
doaj   +1 more source

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Impact of two neighbouring ribosomal protein clusters on biogenesis factor binding and assembly of yeast late small ribosomal subunit precursors.

PLoS ONE, 2019
Many of the small ribosomal subunit proteins are required for the stabilisation of late small ribosomal subunit (SSU) precursors and for final SSU rRNA processing in S. cerevisiae.
Jan Linnemann, Gisela Pöll, Steffen Jakob, Sébastien Ferreira-Cerca, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit   +6 more
doaj   +1 more source

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source

ELOVL4 protein preferentially elongates 20:5n3 to very long chain PUFAs over 20:4n6 and 22:6n3

Journal of Lipid Research, 2012
We hypothesized that reduction/loss of very long chain PUFAs (VLC-PUFAs) due to mutations in the ELOngase of very long chain fatty acid-4 (ELOVL4) protein contributes to retinal degeneration in autosomal dominant Stargardt-like macular dystrophy (STGD3 ...
Man Yu, Aaron Benham, Sreemathi Logan, R. Steven Brush, Md Nawajes A. Mandal, Robert E. Anderson, Martin-Paul Agbaga   +6 more
doaj   +1 more source