Results 91 to 100 of about 369,882 (213)

Post-translational processing of an O-glycosylated protein, the human CD8 glycoprotein, during the intracellular transport to the plasma membrane.

Journal of Biological Chemistry, 1992
The biosynthesis of human CD8 glycoprotein in transfected rat epithelial cells produces an unglycosylated precursor, an intermediate species only initially O-glycosylated, and a doublet mature form carrying neutral and sialylated O-linked oligosaccharides with the core-2 structure (Pascale, M.
PASCALE, Maria, Erra MC, Malagolini N, Serafini Cessi F, Leone A, Bonatti S.   +5 more
openaire   +6 more sources

N-terminal proteomics assisted profiling of the unexplored translation initiation landscape in Arabidopsis thaliana [PDF]

, 2017
Proteogenomics is an emerging research field yet lacking a uniform method of analysis. Proteogenomic studies in which N-terminal proteomics and ribosome profiling are combined, suggest that a high number of protein start sites are currently missing in ...
Gevaert, Kris, Jonckheere, Veronique, Martens, Lennart, Ndah, Elvis, Stael, Simon, Sticker, Adriaan, Van Breusegem, Frank, Van Damme, Petra, Willems, Patrick   +8 more
core   +1 more source

cAMP-dependent protein kinase regulates post-translational processing and expression of complex I subunits in mammalian cells

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Work is presented on the role of cAMP-dependent protein phosphorylation in post-translational processing and biosynthesis of complex I subunits in mammalian cell cultures. PKA-mediated phosphorylation of the NDUFS4 subunit of complex I promotes in cell cultures in vivo import/maturation in mitochondria of the precursor of this protein.
Papa, Sergio, Scacco, Salvatore, De Rasmo, Domenico, Signorile, Anna, Papa, Francesco, Panelli, Damiano, Nicastro, Annarita, Scaringi, Raffaella, Santeramo, Arcangela, Roca, Emilio, Trentadue, Raffaella, Larizza, Maria   +11 more
openaire   +4 more sources

A quantitative comparison of sRNA-based and protein-based gene regulation [PDF]

, 2008
Small, non-coding RNAs (sRNAs) play important roles as genetic regulators in prokaryotes. sRNAs act post-transcriptionally via complementary pairing with target mRNAs to regulate protein expression.
Berg HC, Ned S Wingreen, Pankaj Mehta, Ptashne M, Sidhartha Goyal, van Kampen NG   +5 more
core   +3 more sources

How proteins are transported into mitochondria [PDF]

, 1981
Most mitochondrial polypeptides are synthesized outside the organelle as precursors which are usually larger than the ‘mature’ polypeptides found within mitochondria.
Neupert, Walter, Schatz, Gottfried
core   +1 more source

Biosynthesis and enzymology of the Caenorhabditis elegans cuticle: identification and characterization of a novel serine protease inhibitor. [PDF]

, 2006
The nematode Caenorhabditis elegans represents an excellent model in which to examine nematode gene expression and function. A completed genome, straightforward transgenesis, available mutants and practical genome-wide RNAi approaches provide an ...
Andrew J. Birnie, Antony P. Page, Brenner, Brooks, Canty, Chu, Davis, Edens, Eschenlauer, Frand, Friedman, Gillian McCormack, Hawdon, Hill, Johnstone, Kamath, Kamath, Kramerova, Kramerova, Kress, Lustigman, Milstone, Myllyharju, Myllyharju, Novelli, Page, Page, Page, Page, Page, Pappano, Peters, Poole, Roberts, Sapio, Simmer, Singh, Sulston, Thacker, Thacker, Thein, Winter, Yang   +42 more
core   +1 more source

Post-transcriptional control by bacteriophage T4: mRNA decay and inhibition of translation initiation

Virology Journal, 2010
Over 50 years of biological research with bacteriophage T4 includes notable discoveries in post-transcriptional control, including the genetic code, mRNA, and tRNA; the very foundations of molecular biology.
Miller Eric S, Uzan Marc
doaj   +1 more source

cAMP dependent protein kinase regulates expression and post-translational processing of respiratory chain complex I in mammalian cells

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2010
Work is presented on the role of cAMP-dependent protein phosphorylation in post-translational processing and biosynthesis of complex I subunits in mammalian cell cultures. PKA-mediated phosphorylation of the NDUFS4 subunit of complex I promotes in cell cultures in vivo import/maturation in mitochondria of the precursor of this protein.
Papa S., De Rasmo D., Panelli D., Nicastro A., Scaringi R., Santeramo A., Roca E., Trentadue R., Larizza M., SCACCO, Salvatore, SIGNORILE, ANNA, PAPA, Francesco   +11 more
openaire   +3 more sources

Biological significance of complex N-glycans in plants and their impact on plant physiology

Frontiers in Plant Science, 2014
Asparagine (N)-linked protein glycosylation is a ubiquitous co- and post-translational modification which can alter the biological function of proteins and consequently affects the development, growth and physiology of organisms.
Richard eStrasser
doaj   +1 more source

Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury [PDF]

, 2017
Objective: Exposure to repetitive concussion, or mild traumatic brain injury (mTBI), has been linked with increased risk of long-term neurodegenerative changes, specifically chronic traumatic encephalopathy (CTE).
Acker, Christopher M., Ait-Ghezala, Ghania, Bachmeier, Corbin, Crawford, Fiona, Crynen, Gogce, Davies, Peter, Ferguson, Scott, Mouzon, Benoit C., Mullan, Michael, Ojo, Joseph O., Paris, Daniel, Stewart, William   +11 more
core   +2 more sources