Results 141 to 150 of about 22,982,554 (304)
Modern Approaches To Quality Control
Rapid advance have been made in the last decade in the quality control procedures and techniques, most of the existing books try to cover specific techniques with all of their details. The aim of this book is to demonstrate quality control processes in a
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Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Protein Oxidation, Quality-Control Mechanisms and Parkinson’s Disease
Proteostasis is defined as the integrated mechanisms within cells that control protein biogenesis, folding, trafficking and degradation. The integrity of the proteome is essential for cellular homeostasis, function and survival and is continuously ...
Rodrigo Franco +2 more
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The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Pedoman Quality Control , merupakan pedoman yang diterapkan pada pelatihan yang diselenggarakan baik di pusat maupun daerah, dengan semakin berkembangnya ilmu pengetahuan dan teknologi serta semakin meningkatnya kebutuhan masyarakat terhadap pelayanan ...
Pusdiklat Aparatur
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Colorado Air Quality Control Commission report to the public 2006-2007
Report to the Public 2006-2007 Colllorrado UNION CONSTITUTION AND Colorado Department of Public Health and Environment Air Quality Control Commission The Report to the Public is issued by the Colorado Air Quality Control Commission and prepared by the ...
Colorado. Air Quality Control Commission;
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Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane
Peripheral Quality Control Protein misfolding diseases often lead to the retention and degradation of important proteins within the endoplasmic reticulum (ER).
Jörg Höhfeld +7 more
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