Results 171 to 180 of about 1,305,355 (298)

Architecture of the UBR4 complex, a giant E4 ligase central to eukaryotic protein quality control. [PDF]

Science
Grabarczyk DB, Ehrmann JF, Murphy P, Yang WS, Kurzbauer R, Bell LE, Deszcz L, Neuhold J, Schleiffer A, Shulkina A, Lee J, Shin JS, Meinhart A, Versteeg GA, Zavodszky E, Song HK, Hegde RS, Clausen T.   +17 more
europepmc   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Protein quality control and antigen presentation in the development of hepatitis B-related hepatocellular carcinoma. [PDF]

Front Pharmacol
An L, Han Y, Sun X, Wang L, Guo L.
europepmc   +1 more source

C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains. [PDF]

EMBO Rep, 2023
Jülg J, Edbauer D, Behrends C.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Protein quality control systems in neurodegeneration - culprits, mitigators, and solutions? [PDF]

Front Neurol
Ciechanover A, Livneh I.
europepmc   +1 more source

The Effect of Calorie Restriction on Protein Quality Control in Yeast. [PDF]

Biomolecules, 2023
Uvdal P, Shashkova S.
europepmc   +1 more source

Analysis of High-Throughput Data - Protein-Protein Interactions, Protein Complexes and RNA Half-life

, 2009
The development of high-throughput techniques has lead to a paradigm change in biology from the small-scale analysis of individual genes and proteins to a genome-scale analysis of biological systems.
Friedel, Caroline Christina
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