Protein S-glutathionylation and platelet anti-aggregating activity of disulfiram
Biochemical Pharmacology, 2006 Blood platelets are central to haemostasis, and reactions in platelets involving sulfhydryl groups play important roles in platelet function. Reduced glutathione (GSH) plays an important role in platelet aggregation and glutathione-depleting chemicals inhibit platelet aggregation.
Rossi, Ranieri +3 more
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Redox-dependent protein S-glutathionylation governs azacitidine sensitivity and resistance in AML [PDF]
Redox BiologyDisruption of redox metabolism is a hallmark of drug-resistant cancer cells, representing a major obstacle to the effective treatment of acute myeloid leukemia (AML).
Dušan Nemes +5 more
doaj +2 more sources
Frontiers in Cardiovascular Medicine, 2023 The discovery that cardiac sarcomere proteins are substrates for S-glutathionylation and that this post-translational modification correlates strongly with diastolic dysfunction led to new concepts regarding how levels of oxidative stress affect the ...
Paola C. Rosas, R. John Solaro
doaj +3 more sources
Glutathione in Protein Redox Modulation through S-Glutathionylation and S-Nitrosylation [PDF]
Molecules, 2021 S-glutathionylation and S-nitrosylation are reversible post-translational modifications on the cysteine thiol groups of proteins, which occur in cells under physiological conditions and oxidative/nitrosative stress both spontaneously and enzymatically ...
Elena Kalinina, Maria Novichkova
doaj +4 more sources
Redox Regulation by Protein S-Glutathionylation: From Molecular Mechanisms to Implications in Health and Disease [PDF]
International Journal of Molecular Sciences, 2020 Yuh-Cherng Chai
exaly +2 more sources
Enduring Reactive Oxygen Species Emission Causes Aberrant Protein S-Glutathionylation Transitioning Human Aortic Valve Cells from a Sclerotic to a Stenotic Phenotype. [PDF]
Antioxid Redox Signal, 2022 Aims: During calcific aortic valve stenosis (CAVS) progression, oxidative stress and endothelial dysfunction mark the initial pathogenic steps with a parallel dysregulation of the antioxidant systems.
Valerio V +12 more
europepmc +4 more sources
ROS-Driven STAT1 S-Glutathionylation Sustains IFNγ Signaling and Pro-Inflammatory Microglial Polarization [PDF]
AntioxidantsOxidative stress is a major driver of neuroinflammation, yet the molecular redox mechanisms that shape microglial activation remain incompletely defined.
Martina Brattini +8 more
doaj +2 more sources
Protein S ‐glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells [PDF]
FASEB Journal, 2020 Kazuhiro Watanabe +2 more
exaly +2 more sources
The Role of S-Nitrosylation and S-Glutathionylation of Protein Disulphide Isomerase in Protein Misfolding and Neurodegeneration [PDF]
International Journal of Cell Biology, 2013 Neurodegenerative diseases involve the progressive loss of neurons, and a pathological hallmark is the presence of abnormal inclusions containing misfolded proteins.
M. Halloran, S. Parakh, J. D. Atkin
doaj +3 more sources
Measurement of S-glutathionylated proteins by HPLC [PDF]
Amino Acids, 2021 AbstractS-glutathionylated proteins (GSSP), i.e., protein-mixed disulfides with glutathione (GSH), are considered a suitable biomarker of oxidative stress. In fact, they occur within cells at low level and their concentration increases markedly under pro-oxidant conditions.
Giustarini, Daniela +3 more
openaire +5 more sources