Results 1 to 10 of about 11,635 (216)
Redox Biology, 2014 Glutaredoxin 2 is a vertebrate specific oxidoreductase of the thioredoxin family of proteins modulating the intracellular thiol pool. Thereby, glutaredoxin 2 is important for specific redox signaling and regulates embryonic development of brain and ...
Carsten Berndt +2 more
exaly +4 more sources
Antioxidants, 2018 Leguminous plants can form a symbiotic relationship with Rhizobium bacteria, during which plants provide bacteria with carbohydrates and an environment appropriate to their metabolism, in return for fixed atmospheric nitrogen.
Genevieve Alloing +2 more
exaly +5 more sources
Activation of 3-Mercaptopyruvate Sulfurtransferase by Glutaredoxin Reducing System
Biomolecules, 2020 Glutaredoxin (EC 1.15–1.21) is known as an oxidoreductase that protects cysteine residues within proteins against oxidative stress. Glutaredoxin catalyzes an electron transfer reaction that donates an electron to substrate proteins in the reducing system
Noriyuki Nagahara
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Protein Glutathionylation and Glutaredoxin: Role in Neurodegenerative Diseases
Antioxidants, 2022 Oxidative stress has been implicated in the pathogenesis and progression of many neurodegenerative disorders including Parkinson’s disease and Alzheimer’s disease.
Haseena P. A. +2 more
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Making HEDS or tails of glutaredoxin catalysis: Direct reduction of bis(2-hydroxyethyl) disulfide as a non-glutathione disulfide substrate [PDF]
Redox BiologyThe bis(2-hydroxyethyl) disulfide (HEDS) steady-state assay is the most commonly used assay to measure the activity and kinetic parameters of glutaredoxins.
Lukas Lang +3 more
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Alterations in the IGF-System and Antioxidant Biomarkers in Young Brazilian Adults with Type 1 Diabetes: An Analysis of Cardiovascular Risk Factors [PDF]
AntioxidantsChronic hyperglycemia inflicts serious cellular damage by inducing oxidative stress through the excessive production of free radicals. This oxidative milieu may impair the cellular redox capacity and disrupt the insulin-like growth factor (IGF) system ...
Michael Tekle +6 more
doaj +2 more sources
Silver Binding to Bacterial Glutaredoxins Observed by NMR
Biophysica, 2021 Glutaredoxins (GRXs) are a class of enzymes used in the reduction of protein thiols and the removal of reactive oxygen species. The CPYC active site of GRX is a plausible metal binding site, but was previously theorized not to bind metals due to its cis ...
Stephanie M. Bilinovich +8 more
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The SP/NK1R System-Mediated ROS Generation in GBM Cells through Inhibiting Glutaredoxin Protein
Neurology Research International, 2021 Altered redox balance is among the main contributing factors developing glioblastoma multiforme (GBM), a highly aggressive grade IV brain tumor. Neuropeptide substance P (SP) plays a key role in modifying the cellular redox environment by activating the ...
Negeen Mehrabani +4 more
doaj +1 more source
Antioxidants, 2022 Free fatty acids (FFA), hyperglycemia, and inflammatory cytokines are major mediators of β-cell toxicity in type 2 diabetes mellitus, impairing mitochondrial metabolism.
Sebastian Friedrich Petry +10 more
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S-Denitrosylation: A Crosstalk between Glutathione and Redoxin Systems
Antioxidants, 2022 S-nitrosylation of proteins occurs as a consequence of the derivatization of cysteine thiols with nitric oxide (NO) and is often associated with diseases and protein malfunction.
Surupa Chakraborty +8 more
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