Results 21 to 30 of about 11,635 (216)

Intracellular glutathione pools are heterogeneously concentrated [PDF]

, 2013
Glutathione is present in millimolar concentrations in the cell, but its relative distribution among cellular compartments remains elusive. We have chosen the endoplasmic reticulum (ER) as an example organelle to study compartment-specific glutathione ...
Christine Tachibana, Jakob Rahr Winther, Rahr Winther, Jakob, Winther, Jakob R., Appenzeller-Herzog, Christian, Davide Montero, Tachibana, Christine, Christian Appenzeller-Herzog, Montero, Davide   +8 more
core   +1 more source

Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

mBio, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent for coronavirus disease 2019 (COVID-19), encodes two proteases required for replication.
David A. Davis, Haydar Bulut, Prabha Shrestha, Amulya Yaparla, Hannah K. Jaeger, Shin-ichiro Hattori, Paul T. Wingfield, John J. Mieyal, Hiroaki Mitsuya, Robert Yarchoan   +9 more
doaj   +1 more source

Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum. [PDF]

, 2009
The malarial parasite Plasmodium falciparum possesses a functional thioredoxin and glutathione system comprising the dithiol-containing redox proteins thioredoxin (Trx) and glutaredoxin (Grx), as well as plasmoredoxin (Plrx), which is exclusively found ...
Sturm, Nicole, Becker Katja, Koncarevic, Sasa, Forchhammer, Karl, Mailu, Boniface M., Rahlfs, Stefan, Katja Becker, Deponte, Marcel, Koncarevic Sasa, Becker, Katja, Sturm Nicole, Mailu Boniface M., Marcel Deponte, Deponte Marcel, Jortzik, Esther, Stefan Rahlfs, Jortzik Esther, Esther Jortzik, Karl Forchhammer, Nicole Sturm, Forchhammer Karl, Boniface M Mailu, Sasa Koncarevic, Rahlfs Stefan   +23 more
core   +1 more source

Glutaredoxins: roles in iron homeostasis [PDF]

Trends in Biochemical Sciences, 2010
Glutaredoxins, proteins traditionally involved in redox reactions, are also required for iron-sulfur cluster assembly and haem biosynthesis. These new roles are probably related to the ability of some glutaredoxins to bind labile [2Fe-2S] clusters and to transfer them rapidly and efficiently to acceptor proteins.
Rouhier, Nicolas, Couturier, Jérémy, Johnson, Michael, Jacquot, Jean-Pierre   +3 more
openaire   +4 more sources

The impact of glutaredoxin 1 and glutaredoxin 2 double knockout on lens epithelial cell function

Experimental Eye Research, 2023
Glutaredoxins (Grx1 and Grx2) are thiol-repair antioxidant enzymes that play vital roles in cellular redox homeostasis and various cellular processes. This study aims to evaluate the functions of the glutaredoxin (Grx) system, including glutaredoxin 1 (Grx1) and glutaredoxin 2 (Grx2), using Grx1/Grx2 double knockout (DKO) mice as a model.
Jinmin, Zhang, Yu, Yu, Terry, Dang, Kevin, Lal, Hongli, Wu   +4 more
openaire   +2 more sources

An NMR-Guided Screening Method for Selective Fragment Docking and Synthesis of a Warhead Inhibitor

Molecules, 2016
Selective hits for the glutaredoxin ortholog of Brucella melitensis are determined using STD NMR and verified by trNOE and 15N-HSQC titration. The most promising hit, RK207, was docked into the target molecule using a scoring function to compare ...
Ram B. Khattri, Daniel L. Morris, Caroline M. Davis, Stephanie M. Bilinovich, Andrew J. Caras, Matthew J. Panzner, Michael A. Debord, Thomas C. Leeper   +7 more
doaj   +1 more source

Thiol-based redox regulation in sexual plant reproduction: new insights and perspectives

Frontiers in Plant Science, 2013
The success of sexual reproduction in plants involves (i) the proper formation of the plant gametophytes (pollen and embryo sac) containing the gametes, (ii) the accomplishment of specific interactions between pollen grains and the stigma, which ...
Jose A Traverso, Amada ePulido, Maria Isabel Rodríguez-García, Juan De Dios Alché   +3 more
doaj   +1 more source

Analysis of Thioredoxins and Glutaredoxins in Soybean: Evidence of Translational Regulation under Water Restriction

Antioxidants, 2022
Soybean (Glycine max (L.) Merr.) establishes symbiosis with rhizobacteria, developing the symbiotic nodule, where the biological nitrogen fixation (BNF) occurs.
María Martha Sainz, Carla Valeria Filippi, Guillermo Eastman, José Sotelo-Silveira, Omar Borsani, Mariana Sotelo-Silveira   +5 more
doaj   +1 more source

Cysteine Specific Targeting of the Functionally Distinct Peroxiredoxin and Glutaredoxin Proteins by the Investigational Disulfide BNP7787

Molecules, 2015
Glutaredoxin (Grx), peroxiredoxin (Prx), and thioredoxin (Trx) are redoxin family proteins that catalyze different types of chemical reactions that impact cell growth and survival through functionally distinct intracellular pathways.
Aulma R. Parker, Pavankumar N. Petluru, Vicki L. Nienaber, John Badger, Betsy D. Leverett, Kamwing Jair, Vandana Sridhar, Cheyenne Logan, Philippe Y. Ayala, Harry Kochat, Frederick H. Hausheer   +10 more
doaj   +1 more source

Relationships between the Reversible Oxidation of the Single Cysteine Residue and the Physiological Function of the Mitochondrial Glutaredoxin S15 from Arabidopsis thaliana

Antioxidants, 2022
Glutaredoxins (GRXs) are widespread proteins catalyzing deglutathionylation or glutathionylation reactions or serving for iron-sulfur (Fe-S) protein maturation. Previous studies highlighted a role of the Arabidopsis thaliana mitochondrial class II GRXS15
Loïck Christ, Jérémy Couturier, Nicolas Rouhier   +2 more
doaj   +1 more source