Results 81 to 90 of about 4,630,754 (316)
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Molecular Metabolism, 2018 Objective: To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation, apoptosis and ER stress, with the objective to assess its potential as a screening ...
Violeta Georgieva Tsonkova +35 more
doaj +1 more source
Protein-RNA interactions: a structural analysis
, 2001 A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single ...
Daley, DT +9 more
core
, 2013 Network modelling provides an increasingly popular conceptualisation in a wide range of domains, including the analysis of protein structure. Typical approaches to analysis model parameter values at nodes within the network. The spherical locality around
Ross, Isla +9 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Nature Communications, 2017 GABAergic transmission regulates the K+-Cl− co-transporter KCC2. Here the authors demonstrate that inhibitory transmission, via GABAA receptor and WNK signaling, regulates KCC2 expression in the membrane of hippocampal neurons.
Martin Heubl +11 more
doaj +1 more source
Der p 5 allergen from house dust mite: first epitope mapping of rabbit IgG blocking antibodies
New Microbes and New Infections, 2019 Der p 5 is one of the important house dust mite allergens in Algeria; this allergen is frequently recognized by patients with allergic asthma. However, there is no information on its IgG–binding epitopes. In the present study, rabbits were immunized with
S. Lahiani +3 more
doaj +1 more source
Formation and properties of S‐protein complex with S‐peptide‐containing fusion protein
FEBS Letters, 1994 A fusion protein (FP) comprised of the RNase A S‐peptide and human epidermal growth factor was shown to form a stable noncovalent catalytically active complex with the RNase A S‐protein at a stoichiometric ratio 1:1 with K diss = 5.0 × 10−7M. The S‐protein complex with FP exhibits the pyrimidine specificity toward substrates in both reactions catalyzed
Karpeisky, M.Ya. +3 more
openaire +2 more sources
Prediction of protein-protein interaction types using association rule based classification
, 2009 This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Park et alBackground: Protein-protein interactions (PPI) can be classified according to their characteristics into, for example obligate or transient ...
José A Reyes +14 more
core +1 more source
Protein alignment HW/SW optimizations [PDF]
, 2012 Biosequence alignment recently received an amazing support from both commodity and dedicated hardware platforms. The limitless requirements of this application motivate the search for improved implementations to boost processing time and capabilities. We
M. Zamboni +11 more
core +1 more source