Results 71 to 80 of about 4,630,754 (316)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Analysis of leukocyte membrane protein interactions using protein microarrays

, 2005
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work
Foster-Cuevas, M, Letarte, Michelle, Deborah Hatherley, Foster-Cuevas, Mildred, Hatherley, D, Barclay, AN, Michelle Letarte, Saunders, Nigel, A Neil Barclay, Saunders, NJ, Hatherley, Deborah, Letarte, M, Barclay, Neil, Mildred Foster-Cuevas, Nigel J Saunders, Saunders, Nigel J, Voulgaraki, D, Despina Voulgaraki, Voulgaraki, Despina   +18 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Activity of protein C, protein S and antithrombin 3 in COVID-19 patients treated with different modalities of oxygen supplementation

Türk Biyokimya Dergisi
COVID-19 in it is more severe form is characterized by a hyperinflammatory condition, hypercoagulation state and the appearance of pulmonary microembolism.
Ana Šavuk, Danijela Grizelj, Tomo Svaguša, Melanie-Ivana Čulo, Nikola Zagorec, Sara Šakota, Biserka Orehovec, Tomislav Kelava, Ana Livun, Ivan Marković, Josip Baković, Tatjana Kereš   +11 more
doaj   +1 more source

Upregulation of protein S by progestins [PDF]

Journal of Thrombosis and Haemostasis, 2007
Users of progestin-only contraceptives have raised protein S (PS) levels compared with baseline. This contrasts with the reduction in PS levels observed in users of combined oral contraceptives, which contain both a progestin and an estrogen.To determine the effect of progesterone and other progestin isoforms on the expression of PS and to describe the
Q, Hughes, M, Watson, V, Cole, M, Sayer, R, Baker, J, Staton   +5 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Role and Mechanisms of Tyro3 in Podocyte Biology and Glomerular Disease

Kidney Diseases
Background: Podocyte loss occurs in both primary and secondary glomerular diseases, leading to the progression of kidney disease. A large body of evidence suggests that apoptosis and detachment are the mechanisms mediating the reduction in podocyte ...
Lulin Min, Yixin Chen, Fang Zhong, Leyi Gu, Kyung Lee, John Cijiang He   +5 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Regulated increase in folding capacity prevents unfolded protein stress in the ER

, 2010
Stimulation of thyrocytes with thyroid stimulating hormone (TSH) leads to a morphological change and a massive increase in thyroglobulin (Tg) production.
Mkrtchian, S., Schildknegt, D., Fullaondo, A., Sub Cellular Protein Chemistry, Heck, A.J.R., Braakman, L.J., Christis, C., Cellular Protein Chemistry, Dep Scheikunde, Sub Biomol.Mass Spectrometry & Proteom., Biomolecular Mass Spectrometry and Proteomics, Sub Biomol.Mass Spect. and Proteomics   +11 more
core   +1 more source

Versatile members of the DNAJ family show Hsp70 dependent anti-aggregation activity on RING1 mutant parkin C289G [PDF]

, 2016
Parkinson's disease is one of the most common neurodegenerative disorders and several mutations in different genes have been identified to contribute to the disease.
Pandey, Abhinav, Sub Cellular Protein Chemistry, Kuiper, E F Elsiena, Kuiper, E. F. Elsiena, Kampinga, Harm H., Kuiper, E. F. Elsiena; id_orcid, Kakkar, Vaishali, Kampinga, Harm H.; id_orcid, Kampinga, Harm H, Braakman, Ineke, Cellular Protein Chemistry   +10 more
core   +1 more source