Results 241 to 250 of about 24,775,971 (291)
Severe Protein S Deficiency in a Newborn
Pediatrics, 1992 Protein S is a vitamin K-dependent glycoprotein which acts as a cofactor for the anticoagulant activity of protein C.1,2 With production under autosomal control, heterozygotes produce half-normal levels and thrombotic disease may develop.3-6 Although thromboses occur primarily in adults, there are isolated reports of their occurrence in affected ...
Gaston Zilleruelo, Charles H Pegelow
exaly +4 more sources
Protein S mRNA in Patients with Protein S Deficiency
Thrombosis and Haemostasis, 1995 SummaryA protein S gene polymorphism, detectable by restriction analysis (BstXI) of amplified exonic sequences (exon 15), was studied in seven Italian families with protein S deficiency. In the 17 individuals heterozygous for the polymorphism the study was extended to platelet mRNA through reverse transcription, amplification and densitometric analysis.
SACCHI E +6 more
openaire +3 more sources
Some of the next articles are maybe not open access.
Related searches:
Related searches:
Seminars in Thrombosis and Hemostasis, 1999
Protein C and S deficiency states predispose affected individuals to thrombosis, especially venous thrombosis of the lower extremities, usually beginning in the teenage years. Treatment of these patients is generally with oral anticoagulation, following initial heparinization.
F A, Nizzi, H S, Kaplan
exaly +3 more sources
Protein C and S deficiency states predispose affected individuals to thrombosis, especially venous thrombosis of the lower extremities, usually beginning in the teenage years. Treatment of these patients is generally with oral anticoagulation, following initial heparinization.
F A, Nizzi, H S, Kaplan
exaly +3 more sources
Protein S deficiency in pregnancy
American Journal of Obstetrics and Gynecology, 1986The case of a primigravid patient with protein S deficiency, a rare disorder resulting in recurrent venous thrombosis, was managed with prophylactic heparin therapy and elective pregnancy termination. Although rarely diagnosed, protein S deficiency may become more commonly identified with wider application of protein S assays.
John T Brandt
exaly +3 more sources
Analytical Considerations for Free Protein S Assays in Protein S Deficiency
Thrombosis and Haemostasis, 2001 SummaryProtein S is an anticoagulant protein that circulates in plasma in complex with C4b-binding protein (C4BP) or in free form. Deficiency of protein S increases the risk of venous thrombosis. Measurement of free protein S, as compared to total levels, has been shown to be superior for prediction of protein S deficiency.
K E, Persson, A, Hillarp, B, Dahlbäck
core +4 more sources
Thrombosis and Haemostasis, 1997
The protein C (PC) pathway, with its cofactor protein S (PS), is an important natural antithrombotic mechanism. Patients with phenotypic PS deficiency may develop recurrent thrombosis during adulthood, with a probability of remaining free of thrombosis of about 50% at age 45.
D, Borgel, S, Gandrille, M, Aiach
openaire +2 more sources
The protein C (PC) pathway, with its cofactor protein S (PS), is an important natural antithrombotic mechanism. Patients with phenotypic PS deficiency may develop recurrent thrombosis during adulthood, with a probability of remaining free of thrombosis of about 50% at age 45.
D, Borgel, S, Gandrille, M, Aiach
openaire +2 more sources
Moyamoya syndrome with protein S deficiency
European Journal of Paediatric Neurology, 2000Moyamoya disease is a cerebrovascular disease with progressive occlusion of both internal carotid arteries and of their branches and formation of a new vascular network at the base of the brain. Because of the angiographic appearance, it is named as moyamoya.
D, Akgün +4 more
openaire +2 more sources
Molecular basis of protein S deficiency
Thrombosis and Haemostasis, 2007SummaryProtein S deficiency (PSD) has been the most difficult to study among the classical inherited thrombophilic factors. This is in part due to the peculiar biology of protein S (PS), which has an anticoagulant role but no enzymatic activity,and because it interacts with plasma components that function in both haemostasis and inflammation.Clinically,
García de Frutos, Pablo +3 more
openaire +3 more sources
The Clinical Investigator, 1992
Hereditary deficiencies of coagulation inhibitors like antithrombin III, protein C and protein S lead to an enhanced incidence of thromboembolic complications. Recently, acquired deficiencies of protein S were described in several disease states in which thromboembolic complications frequently occur. These acquired protein S deficiencies reach--in part-
openaire +2 more sources
Hereditary deficiencies of coagulation inhibitors like antithrombin III, protein C and protein S lead to an enhanced incidence of thromboembolic complications. Recently, acquired deficiencies of protein S were described in several disease states in which thromboembolic complications frequently occur. These acquired protein S deficiencies reach--in part-
openaire +2 more sources
Arterial thrombosis and protein S deficiency
The Journal of Pediatrics, 1992A previously healthy boy had progressive painful discoloration of the lower extremities and was treated with exchange transfusion and anticoagulation, which were unsuccessful in arresting pedal ischemia; amputation of all of the child's toes was required. Studies of the patient and his parents resulted in a diagnosis of inherited protein S deficiency.
I N, Horowitz +2 more
openaire +2 more sources