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Hereditary Protein S Deficiency

Haemostasis, 2009
Protein S is a vitamin K-dependent plasma protein that serves as a cofactor of activated protein C (APC) in its inhibitory action on activated factor V and factor VIII and in its stimulation of fibrinolytic activity. In plasma, part of the protein S is complexed with the C4b-binding protein. Only the free protein S has APC cofactor activity.
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Analysis of the Protein S Gene in Protein S Deficiency

2003
Protein S (PS) is a 71-kDa vitamin K-dependent glycoprotein first identified in human plasma by DiScipio and colleagues in 1977 (1), a year after the discovery of the anticoagulant protein C (PC) (2,3). A few years later, Walker demonstrated that PS acts as a cofactor for activated protein C (APC) in the proteolytic inactivation of the procoagulant ...
N, Sala, Y, Espinosa-Parrilla
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Arterial Thrombosis and Protein S Deficiency

Thrombosis and Haemostasis, 1989
Dosage par immunoelectrophorese du taux plasmatique de l'antigene de la proteine S chez des patients souffrant d'une thrombose arterielle; correlation entre le deficit en proteine S et la ...
Sie, P   +5 more
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Serendipitous Diagnosis of Protein S Deficiency

Journal of Periodontology, 2002
A 46‐year‐old male sought periodontal care for a swelling on his right mandibular gingiva. An excisional biopsy revealed a well‐differentiated squamous cell carcinoma. Surgical treatment consisted of a right segmental mandibulectomy with ipsilateral right neck dissection and fibular free flap reconstruction.
A, Aguirre   +3 more
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Inhibition of Protein S by Autoantibodies in Patients with Acquired Protein S Deficiency

Thrombosis and Haemostasis, 1996
SummaryThis study was undertaken to analyze antibodies to protein S (PS) in patients with an acquired PS deficiency. Plasma from symptomatic patients with acquired (n = 14) or congenital (n = 10) PS deficiency and 10 healthy donors was screened for PS antibodies by immunoblotting and for anti-phospholipid antibodies.
SORICE, Maurizio   +7 more
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Hyperhomocysteinaemia and protein S deficiency in complicated pregnancies

BJOG: An International Journal of Obstetrics & Gynaecology, 1997
Objective The aim of our study was to investigate whether women with placental abruption, intrauterine fetal death or small for gestational age infants have metabolic and/or haemostatic abnormalities which are known to be risk factors for intravascular thrombosis.Design For two years blood tests were performed at > 10 weeks after ...
de Vries, J.I.P.   +5 more
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Protein C and S Deficiencies

2018
This chapter discusses the pathophysiology, inheritance, and epidemiology of protein C and protein S deficiencies. The chapter discusses the impact of protein C and protein S deficiencies on pregnant women and details suggested medical and anesthetic management of affected individuals.
James P. R. Brown, Joanne Douglas
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PROTEIN S DEFICIENCY AND ANTIBODIES TO PROTEIN S IN PATIENTS WITH BEHCET'S DISEASE

Thrombosis Research, 1997
Thrombosis occurs in 20 to 30% of patients with Behçet's disease (BD). Most of the reported hemostatic abnormalities are related to the inflammatory syndrome. We have assessed the activity of antithrombin III, protein C and protein S (PS), in 30 patients with BD and in 30 healthy controls. Thrombosis antecedents were found in 16 patients.
S, Guermazi, M, Hamza, K, Dellagi
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Hereditary protein S deficiency

2020
Venous thrombosis is a multifactorial disease, that genetic and environmental factors play a part. Especially, in the patients who have experienced recurrent venous thromboembolisms (VTE) and also in their relatives with similar clinical features; it might present as a congenital coagulation inhibitor deficiency that can cause hereditary thrombotic ...
Dremirağ M.K.   +3 more
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Management of protein S deficiency

The Journal of Pediatrics, 1988
J A, Whitlock, R L, Janco
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