The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley +1 more source
Ensemble deep learning models for protein secondary structure prediction using bidirectional temporal convolution and bidirectional long short-term memory. [PDF]
Yuan L, Ma Y, Liu Y.
europepmc +1 more source
Assessing the Impact of Secondary Structure and Solvent Accessibility on Protein Evolution [PDF]
Nick Goldman+2 more
openalex +1 more source
In the blood–testis barrier, occludin is crucial for tight junctions. This study demonstrates that occludin‐targeting short peptides disrupt junction integrity, inducing immune cell infiltration, tumor necrosis factor‐α/interleukin‐6 secretion and mitochondrial dysfunction, ultimately triggering apoptosis.
Heng Wang, Xiaofang Tan, Deyu Chen
wiley +1 more source
P-SEA: a new efficient assignment of secondary structure from Cα trace of proteins [PDF]
Gilles Labesse+3 more
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d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada+3 more
wiley +1 more source
Lightweight ProteinUnet2 network for protein secondary structure prediction: a step towards proper evaluation. [PDF]
Stapor K+3 more
europepmc +1 more source
Comparison of and limits of accuracy for statistical analyses of vibrational and electronic circular dichroism spectra in terms of correlations to and predictions of protein secondary structure [PDF]
Petr Pančoška+5 more
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The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo+4 more
wiley +1 more source
Editorial: Feature Representation and Learning Methods With Applications in Protein Secondary Structure. [PDF]
Yan N, Lv Z, Hong W, Xu X.
europepmc +1 more source