Results 201 to 210 of about 1,170,066 (317)
Study of secondary structure of protein sequences by linear algebra
Wei-hua Hsieh
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Yi‐Fei‐Jie‐Du‐Tang (YFJDT), a traditional Chinese medicine, has shown potential in lung cancer treatment by targeting key pathways. This study explores the mechanisms of YFJDT using bioinformatics, xenograft models, and A549 cells, demonstrating that YFJDT downregulates HIF1A, promotes ferroptosis, and inhibits epithelial‐mesenchymal transition (EMT ...
Shanshan Wang+6 more
wiley +1 more source
Molecular dynamics of folding of secondary structures in Go-type models of proteins [PDF]
Trinh Xuan Hoang, Marek Cieplak
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Chromatin, which organizes DNA, changes its structure to adapt to stress like high oxygen levels (hyperoxia), which can damage cells. Researchers developed a technique to observe these changes and found variability in how different parts of chromatin remodel.
Lauren Monroe+4 more
wiley +1 more source
Poly‐L‐glutamic acid and poly‐L‐lysine: model substances for studying secondary structures of proteins [PDF]
Tomaž Makovec
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The axolotl's remarkable regenerative abilities decline with age, the causes may include the numerous repetitive elements within its genome. This study uncovers how Ty3 retrotransposons and coexpression networks involving muscle and immune pathways respond to aging and regeneration, suggesting that transposons respond to physiological shifts and may ...
Samuel Ruiz‐Pérez+8 more
wiley +1 more source
Anti‐HIV and anti‐tumor protein MAP30, a 30 kDa single‐strand type‐I RIP, shares similar secondary structure and β‐sheet topology with the A chain of ricin, a type‐II RIP [PDF]
Yun‐Xing Wang+9 more
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Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim+3 more
wiley +1 more source
Analysis of conservation and substitutions of secondary structure elements within protein superfamilies [PDF]
Kenji Mizuguchi, Tom L. Blundell
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Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi+4 more
wiley +1 more source