Results 311 to 320 of about 2,642,890 (372)

Semiconducting Polymer Nanoparticles with Surface‐Mimicking Protein Secondary Structure as Lysosome‐Targeting Chimaeras for Self‐Synergistic Cancer Immunotherapy

Advances in Materials, 2022
Immunotherapy has received tremendous attention for tumor treatment, but the efficacy is greatly hindered by insufficient tumor‐infiltration of immune cells and immunosuppressive tumor microenvironment.
Ji Qi, Shaorui Jia, Xiaoying Kang, Xinying Wu, Yuning Hong, Ke Shan, Xianglong Kong, Zhiming Wang, D. Ding   +8 more
semanticscholar   +1 more source

Secondary Structure and Protein Deamidation

Journal of Pharmaceutical Sciences, 1999
The deamidation reactions of asparagine residues in alpha-helical and beta-turn secondary structural environments of peptides and proteins are reviewed. Both kinds of secondary structure tend to stabilize asparagine residues against deamidation, although the effects are not large.
M, Xie, R L, Schowen
openaire   +2 more sources

Protein Secondary Structure Prediction: A Review of Progress and Directions

Current Bioinformatics, 2020
Over the last few decades, a search for the theory of protein folding has grown into a full-fledged research field at the intersection of biology, chemistry and informatics.
Tomasz Smolarczyk, I. Roterman-Konieczna, K. Stapor   +2 more
semanticscholar   +1 more source

Protein Secondary Structure Prediction

2009
While the prediction of a native protein structure from sequence continues to remain a challenging problem, over the past decades computational methods have become quite successful in exploiting the mechanisms behind secondary structure formation. The great effort expended in this area has resulted in the development of a vast number of secondary ...
Pirovano, W.A., Heringa, J.
openaire   +3 more sources

Protein Secondary Structure Prediction with SPARROW

Journal of Chemical Information and Modeling, 2012
A first step toward predicting the structure of a protein is to determine its secondary structure. The secondary structure information is generally used as starting point to solve protein crystal structures. In the present study, a machine learning approach based on a complete set of two-class scoring functions was used.
Francesco, Bettella, Dawid, Rasinski, Ernst Walter, Knapp   +2 more
openaire   +2 more sources

Chemogenomics with Protein Secondary-Structure Mimetics

2009
During molecular recognition of proteins in biological systems, helices, reverse turns, and beta-sheets are dominant motifs. Often there are therapeutic reasons for blocking such recognition sites, and significant progress has been made by medicinal chemists in the design and synthesis of semirigid molecular scaffolds on which to display amino acid ...
Garland R, Marshall, Daniel J, Kuster, Ye, Che   +2 more
openaire   +2 more sources

Protein Secondary Structure

2010
There are several methods available that can be used to gain information on secondary structure, apart from X-ray crystallography, which remains the ‘gold standard’.
openaire   +1 more source

A Grid-Enabled Protein Secondary Structure Predictor

IEEE Transactions on Nanobioscience, 2007
We present an integrated Grid system for the prediction of protein secondary structures, based on the frequent automatic update of proteins in the training set. The predictor model is based on a feed-forward multilayer perceptron (MLP) neural network which is trained with the back-propagation algorithm; the design reuses existing legacy software and ...
M. MIRTO, CAFARO, Massimo, S. FIORE, DANIELE TARTARINI, ALOISIO, Giovanni   +4 more
openaire   +4 more sources

PSS-SQL: Protein Secondary Structure - Structured Query Language

2010 Annual International Conference of the IEEE Engineering in Medicine and Biology, 2010
Secondary structure representation of proteins provides important information regarding protein general construction and shape. This representation is often used in protein similarity searching. Since existing commercial database management systems do not offer integrated exploration methods for biological data e.g.
Dariusz, Mrozek, Dominika, Wieczorek, Bozena, Malysiak-Mrozek, Stanislaw, Kozielski   +3 more
openaire   +2 more sources

Multiple Alignment Through Protein Secondary-Structure Information

IEEE Transactions on Nanobioscience, 2005
It is well known that protein secondary-structure information can help the process of performing multiple alignment, in particular when the amount of similarity among the involved sequences moves toward the "twilight zone" (less than 30% of pairwise similarity).
Armano G, Milanesi L, Orro A
openaire   +4 more sources