Results 101 to 110 of about 415,112 (277)
Improving the accuracy of protein secondary structure prediction using structural alignment
BMC Bioinformatics, 2006 Background The accuracy of protein secondary structure prediction has steadily improved over the past 30 years. Now many secondary structure prediction methods routinely achieve an accuracy (Q3) of about 75%.
Gallin Warren J +3 more
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
NN-PRED: A novel consensus secondary structure prediction program using neural networks
Revista UIS Ingenierías, 2013 In this paper, a new program for protein secondary structure prediction is proposed. The program, which is called NN-Pred, allows multiple sequences to be submitted and it returns predictions from fve secondary structure prediction algorithms.
Oscar Fernando Bedoya Leiva +1 more
doaj
Predicting residue-wise contact orders in proteins by support vector regression
BMC Bioinformatics, 2006 Background The residue-wise contact order (RWCO) describes the sequence separations between the residues of interest and its contacting residues in a protein sequence.
Burrage Kevin, Song Jiangning
doaj +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Critical Features of Fragment Libraries for Protein Structure Prediction.
PLoS ONE, 2017 The use of fragment libraries is a popular approach among protein structure prediction methods and has proven to substantially improve the quality of predicted structures.
Raphael Trevizani +3 more
doaj +1 more source
Impact of residue accessible surface area on the prediction of protein secondary structures
BMC Bioinformatics, 2008 Background The problem of accurate prediction of protein secondary structure continues to be one of the challenging problems in Bioinformatics. It has been previously suggested that amino acid relative solvent accessibility (RSA) might be an effective ...
Sadeghi Mehdi +3 more
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
BMC Bioinformatics, 2007 Background Structural properties of proteins such as secondary structure and solvent accessibility contribute to three-dimensional structure prediction, not only in the ab initio case but also when homology information to known structures is available ...
Vullo Alessandro +3 more
doaj +1 more source