Results 71 to 80 of about 415,112 (277)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Prediction of 8-state protein secondary structures by a novel deep learning architecture
BMC Bioinformatics, 2018 Background Protein secondary structure can be regarded as an information bridge that links the primary sequence and tertiary structure. Accurate 8-state secondary structure prediction can significantly give more precise and high resolution on structure ...
Buzhong Zhang, Jinyan Li, Qiang Lü
doaj +1 more source
A Factor Graph Approach to Automated GO Annotation [PDF]
, 2016 As volume of genomic data grows, computational methods become essential for providing a first glimpse onto gene annotations. Automated Gene Ontology (GO) annotation methods based on hierarchical ensemble classification techniques are particularly ...
Elizabeth Tapia +4 more
core +3 more sources
Prediction of protein secondary structures from conformational biases [PDF]
Proteins: Structure, Function, and Bioinformatics, 2002 AbstractWe use LINUS (the “Local Independently Nucleated Units of Structure”), a procedure developed by Srinivasan and Rose, to provide a physical interpretation of and predict the secondary structures of proteins. The secondary structure type at a given site is identified by the largest conformational bias during short simulations. We examine the rate
T. X. HOANG +3 more
openaire +3 more sources
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Protein secondary structure prediction: Creating a meta-tool [PDF]
, 2005 only availableProtein structure prediction is a growing field of interest for a many varied reasons, owing not only to its obvious utility, but also the success that applying newer mathematical tools has garnered in recent years.
Bondugula, Rajkumar, 1980- +2 more
core
Prediction of backbone dihedral angles and protein secondary structure using support vector machines [PDF]
, 2009 Background The prediction of the secondary structure of a protein is a critical step in the prediction of its tertiary structure and, potentially, its function.
Petros Kountouris, Jonathan D Hirst
core +2 more sources
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Monte Carlo study of cooperativity in homopolypeptides [PDF]
, 1992 ©1992 American Institute of PhysicsThe electronic version of this article is the complete one and can be found online at: http://link.aip.org/link/?JCPSA6/97/9412/1DOI:10.1063/1.463317A discretized model of globular proteins is employed in a Monte Carlo ...
Kolinski, Andrzej, Skolnick, Jeffrey
core +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source