Results 141 to 150 of about 1,955,826 (316)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

GST protein sequences for 16 plant species from large-scale genomic analysis

Ning Zhang
openalex   +1 more source

Analysis of a Meiosis-Specific URS1 Site: Sequence Requirements and Involvement of Replication Protein A

, 1997
Valérie Gailus‐Durner, Chaya Chintamaneni, Richa Wilson, Steven J. Brill, Andrew K. Vershon   +4 more
openalex   +2 more sources

ANTHEPROT: a package for protein sequence analysis using a microcomputer [PDF]

, 1988
Gilbert Deléage, François Frédéric CLERC, B. Roux, D Gautheron   +3 more
openalex   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The plasma protein fetuin: common structural features of the mammalian fetuin family

, 1991
The structure and tissue-specific expression of the bovine plasma glycoprotein fetuin and its homologues in other species has been examined. From the known partial amino acid sequence of bovine fetuin, degenerate oligonucleotide probes were designed ...
Brown, William Michael
core  

Analysis of sequence variability of the bovine prion protein gene ( PRNP ) in German cattle breeds

, 2004
Petra Sander, H. Hamann, Ina Pfeiffer, Wilhelm Wemheuer, Bertram Brenig, Martin H. Groschup, Ute Ziegler, O. Distl, Tosso Leeb   +8 more
openalex   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Multiple Sequence Alignment and Profile Analysis of Protein Family Utsing Hidden Markov Model

, 2012
Assistant Professor, at LLRIET, Moga, Navjot Kaur, Rajbir Singh Cheema, Harmandeep Singh Harmandeep Singh   +3 more
openalex   +1 more source

Analysis of common bean expressed sequence tags identifies sulfur metabolic pathways active in seed and sulfur-rich proteins highly expressed in the absence of phaseolin and major lectins [PDF]

, 2011
Fuqiang Yin, Agnieszka Pająk, Ralph Chapman, Andrew Sharpe, Shangzhi Huang, Frédéric Marsolais   +5 more
openalex   +1 more source