Results 141 to 150 of about 1,866,516 (263)

StabLyzeGraph: High-throughput screening of combinatorial mutations using graph neural networks. [PDF]

Protein Sci
Waqas M, Natale B, Roggia M, Saha PP, Mileni M, Cosconati S.   +5 more
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Novel GH115 xylan α-1,2-glucuronidases with distinct preferences for xylan-derived oligomers and polymers. [PDF]

Protein Sci
Leontakianakou S, Le SB, Sundin A, Jasilionis A, Nguyen GS, Nordborg A, Gottumukkala LD, Grey C, Lewin AS, Karlsson EN.   +9 more
europepmc   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Conkazal-M1 from the MKAVA family of conotoxins: A dual-function protease inhibitor and neuroactive peptide. [PDF]

Protein Sci
Hackney CM, Koch TL, Ryding NL, Rogalski A, Chase K, Giglio ML, Espino SS, Acyatan ZG, Watkins M, Olivera BM, Safavi-Hemami H, Teilum K, Ellgaard L.   +12 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Isolation and Identification of a Novel Variant Rhabdovirus from Cultured Chinese Rice-Field Eels (<i>Monopterus albus</i>) in China. [PDF]

Animals (Basel)
Ou Y, He Y, Li Y, Ren X, Zhou Y, Jiang N, Liu W, Fan Y.   +7 more
europepmc   +1 more source

Cluster Analysis for Protein Sequences

AbstractThis paper presents a comprehensive analysis of MMseqs2 clusters and traditional machine learning (ML) clustering algorithms, including KMeans and Hierarchical clusterings, in terms of protein sequences. The analyses are validated experimentally.
openaire   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Recombinant IL-38 Alleviates Temporomandibular Joint Synovial Inflammation via IL-1R1-NF-κB-IL1β Pathway. [PDF]

Int Dent J
Luo P, Lv X, Hui J, Qiao H.
europepmc   +1 more source