Results 231 to 240 of about 7,767,567 (301)

Deep learning coupled with scalable domain-specific structural validation expands RNA virus discovery from metatranscriptomes. [PDF]

Nat Commun
Luo G, Zang Z, Yuan L, Zhou J, Dong A, Huang Y, Li SZ, Ju F.   +7 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Genome characterization of a begomovirus isolated from Brazilian Carica papaya plants. [PDF]

Arch Virol
Santos YS, do Nascimento EFMB, Bezerra C, Ramírez-Rios V, Vidal AH, Fernandes JEA, Melo FL, Margaria P, Blawid R, Abreu EFM, Ribeiro SG.   +10 more
europepmc   +1 more source

Bi‐ and Mono‐Allelic RFC1 Expansion in a North American Cohort With Idiopathic Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective RFC1 biallelic repeat expansion is increasingly recognized as a cause of chronic idiopathic axonal polyneuropathy (CIAP), but it remains challenging to know who to test. This study aims to determine the prevalence of biallelic and monoallelic RFC1 expansions and their corresponding neuropathy phenotypes in CIAP patients and identify ...
Amro M. Stino, Lavanya Muthukumar, Evan L. Reynolds, Peter Todd, Sinem Ovunc, Sheng Chih Jin, Zitian Tang, Simone Thomas, PNRR Study Group, Ahmet Höke, Brian C. Callaghan, Sarah Berth, Vinay Chaudhry, David Cornblath, Leana Doherty, Lindsey Hayes, Hristelina Ilieva, Thomas Lloyd, Mohammad Khoshnoodi, Brett McCray, Brett Morrison, Bipasha Mukherjee‐Clavin, Lyle Ostrow, Michael Polydefkis, Ricardo Roda, Charlotte Sumner   +25 more
wiley   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Flipons, Noncoding Transcripts and Retroelements: A Universal Host Defense. [PDF]

Int J Mol Sci
Herbert A.
europepmc   +1 more source

Design and validation of nucleosome binding peptides using BindCraft. [PDF]

Front Bioeng Biotechnol
Oleinikov PD, Armeev GA, Sidorkina AE, Rykunova EB, Komarova GA, Motorin NA, Gerasimova NS, Feofanov AV, Studitsky VM, Shaytan AK.   +9 more
europepmc   +1 more source

Knowledge gap in vertebrate genetic diversity in a northern remanent of neotropical rainforest. [PDF]

PLoS One
Martínez Cano DJ, Reynoso VH, Vázquez-Cruz ML, Alvarado-Robledo EJ, Ángeles-López YI, Zarza E.   +5 more
europepmc   +1 more source

VAEBAC: a representation-learning framework for proteome-scale prediction of amyloidogenic proteins and functional stratification of nucleic-acid-binding proteins. [PDF]

Bioinformatics
Ashraf MU, Ahmad O, Khan RH.
europepmc   +1 more source