Results 241 to 250 of about 2,206,167 (301)

Large-scale comparative genomics and structure-function analysis enables characterization of known and novel genetic determinants of antimicrobial resistance in bacterial pathogens. [PDF]

Front Microbiol
Mannion A, Hooks D, Comendul A, Spirgel R.   +3 more
europepmc   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Generative AI and Language Models in Human Genetics and Health: From Variant Interpretation to Clinical Decision Support. [PDF]

Genes (Basel)
Pinchevsky Itan Y, Itan Y.
europepmc   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

SeqHIVE: a Python package to convert the biological sequences to informative vectors for sequence property predictions. [PDF]

BioData Min
Feng X, Gao C, Bai S, Zheng J, Yu C, Li K, Huang L, Han B, You T, Zhang J, Zhou F.   +10 more
europepmc   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Assembly and comparative analysis of the complete mitochondrial genome of <i>Holmskioldia sanguinea</i>. [PDF]

Front Plant Sci
Xu J, Mo X, Zhang J, Yuan L, Xu G.
europepmc   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Identification of <i>Drosophila melanogaster</i> Strain-Specific Sequence Variations in the <i>Nepl15</i> Transcript of Oregon-R relative to FlyBase Data. [PDF]

MicroPubl Biol
Drucker C, Banerjee SJ.
europepmc   +1 more source

Purine bias in bacterial genes is driven by runaway transcription. [PDF]

Nat Microbiol
Dierksheide KJ, Taggart JC, Johnson GE, Li GW.   +3 more
europepmc   +1 more source