Results 261 to 270 of about 7,767,567 (301)
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2006
Publisher Summary This chapter discusses the recent insights into how DNA sequence affects DNA structure and how solvent-mediated alterations in DNA structure may play a role in gene regulation. The stability and sequence specificity of many protein–DNA complexes is remarkably dependent on the sequences of bases that are not in contact with protein ...
Gerald B, Koudelka +2 more
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Publisher Summary This chapter discusses the recent insights into how DNA sequence affects DNA structure and how solvent-mediated alterations in DNA structure may play a role in gene regulation. The stability and sequence specificity of many protein–DNA complexes is remarkably dependent on the sequences of bases that are not in contact with protein ...
Gerald B, Koudelka +2 more
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A recurrent DNA sequence at sites of protein interaction
Advances in Biophysics, 1985Variation in the observed spin lattice relaxation rate (Robs) interpreted as proton exchange dominated in sequences corresponding to part of promoters where RNA polymerase initiates mRNA synthesis has been observed by both Patel et al. and Reid and co-workers.
P, Lu, S, Cheung, M, Donlan
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Thermodynamics of sequence-specific protein-DNA interactions
Biophysical Chemistry, 1996The molecular recognition processes in sequence-specific protein-DNA interactions are complex. The only feature common to all sequence-specific protein-DNA structures is a large interaction interface, which displays a high degree of complementarity in terms of shape, polarity and electrostatics.
T, Härd, T, Lundbäck
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|DNA bending by sequence and proteins
1995Abstract A fundamental problem confronting any living organism is how to package an immense length of DNA in an organised manner into a small volume. One solution is to compact the DNA by the tight bending of the duplex in the form of a superhelix which can itself then be folded into a more compact structure. Because the DNA double helix
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Identification of Sequence-Specific DNA Binding Proteins
2004Publisher Summary This chapter describes methods for the identification of nuclear proteins that bind specific DNA sequences within the cis -regulatory domains of genes. Protocols for the preparation of nuclear extract, quantitative electrophoretic mobility shift analysis, oligonucleotide affinity chromatography, and protein preparation for amino ...
James A, Coffman, Chiou-Hwa, Yuh
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RepEx: A web server to extract sequence repeats from protein and DNA sequences
Computational Biology and Chemistry, 2019Evolution builds up new genetic material from existing ones, not in random, but in highly ordered and eloquent patterns. Most of these sequence repeats are revelatory of valuable information contributing to areas of disease research and function of macromolecules, to name a few.
Daliah Michael +8 more
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A program to optimize DNA sequences for protein expression
Bioinformatics, 1990THOYO is a program that combines sequence feature identification with automatic editing to allow the rapid optimization of «reverse translation» sequence. Data, entered as amino acid sequence in single or triple letter code, is automatically reverse translated using the most frequent codons of man, Saccharomyces cerevisiae or Escherichia ...
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Dual Function of DNA Sequences: Protein-Coding Sequences Function as Transcriptional Enhancers
Perspectives in Biology and Medicine, 2015Most of our genome comprises noncoding sequences that include diverse transcriptional regulatory elements, such as enhancers, while only ~1.5% of the genome codes for proteins. Nevertheless, DNA sequences that code for protein (exons) can also function as enhancers (eExons) that regulate transcription.
Naama, Hirsch, Ramon Y, Birnbaum
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Interaction of regulator proteins with recognition sequences of DNA
Cell, 1974Benjamin Lewin The MIT Press 28 Carleton Street Cambridge, Mass 02142 Although models for the control of gene expression have for some time focused on the concept that regulator proteins act by recognizing specific nu- cleotide sequences, only now is it becoming possi- ble to define the molecular basis of such interac- tions. The existence of two sites
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