Results 91 to 100 of about 261,891 (384)

A Homogeneous Fluorescence Polarization Assay Adaptable for a Range of Protein Serine/Threonine and Tyrosine Kinases

Journal of biomolecular screening, 2003
Recently, a new technology for high-throughput screening has been developed, called IMAP(patent pending). IMAP technology has previously been implemented in an assay for cyclic nucleotide phosphodiesterases (PDE).
E. A. Gaudet, Kuo-Sen Huang, Yan Zhang, Wei Huang, David Mark, J. Sportsman   +5 more
semanticscholar   +1 more source

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease [PDF]

, 2012
A significant amount of evidence suggests that the p38-mitogen-activated protein kinase (MAPK) signalling cascade plays a crucial role in synaptic plasticity and in neurodegenerative diseases.
Corrêa, Sônia A. L., Eales, Katherine L.   +1 more
core   +3 more sources

Diversity in Serine/Threonine Protein Kinase-4 Deficiency and Review of the Literature

The Journal of Allergy and Clinical Immunology: In Practice, 2021
Serine/threonine kinase-4 (STK4) deficiency is an autosomal recessive combined immunodeficiency.We aimed to define characteristic clinical and laboratory features to aid the differential diagnosis and determine the most suitable therapy.In addition to nine STK4 deficiency patients, we reviewed 15 patients from the medical literature.
Deniz Cagdas, Sevil Oskay Halacli, Cagman Tan, Saliha Esenboga, Betül Karaatmaca, Pınar Gur Cetinkaya, Burcu Balcı-Hayta, Arzu Ayhan, Aysegul Uner, Diclehan Orhan, Kaan Boztug, Seza Ozen, Rezan Topaloglu, Ozden Sanal, Ilhan Tezcan   +14 more
openaire   +5 more sources

A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma

BMC Cancer, 2020
Background Cancer recurrence is one of the most concerning clinical problems of cholangiocarcinoma (CCA) patients after treatment. However, an identification of predictive factor on Opisthorchis viverrini (OV)-associated CCA recurrence is not well ...
Sureerat Padthaisong, Malinee Thanee, Nisana Namwat, Jutarop Phetcharaburanin, Poramate Klanrit, Narong Khuntikeo, Attapol Titapun, Watcharin Loilome   +7 more
doaj   +1 more source

HUNK Phosphorylates Rubicon to Support Autophagy [PDF]

, 2019
Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex.
Abt, Melissa, Eblen, Scott T., Muise-Helmericks, Robin, Rhett, J. Matthew, Yeh, Elizabeth S., Zambrano, Joelle N.   +5 more
core   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Biology and pharmacological inhibition of homeodomain-interacting protein kinases

Frontiers in Chemical Biology
Homeodomain-interacting protein kinases (HIPKs) represent a relatively underexplored sub-family of serine/threonine protein kinases. However, the recently published studies point to the role of HIPKs in the developmental biology and etiology of ...
Adam Štefek, Adam Štefek, Kamil Paruch, Kamil Paruch   +3 more
doaj   +1 more source

A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

Molecular Brain, 2009
BackgroundThe signalling mechanisms involved in the induction of N-methyl-D-aspartate (NMDA) receptor-dependent long-term depression (LTD) in the hippocampus are poorly understood.
S. Peineau, C. Nicolas, Z. Bortolotto, Ratan V Bhat, Jonathan Ryves, Adrian J Harwood, P. Dournaud, S. Fitzjohn, G. Collingridge   +8 more
semanticscholar   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Regulation of the Activity of the Dual Leucine Zipper Kinase by Distinct Mechanisms

Cells
The dual leucine zipper kinase (DLK) alias mitogen-activated protein 3 kinase 12 (MAP3K12) has gained much attention in recent years. DLK belongs to the mixed lineage kinases, characterized by homology to serine/threonine and tyrosine kinase, but exerts ...
Kyra-Alexandra Köster, Marten Dethlefs, Jorge Duque Escobar, Elke Oetjen   +3 more
doaj   +1 more source