Results 141 to 150 of about 142,215 (332)

TRIB3 suppresses milk fatty acids metabolism by inhibiting p‐AKT/PPARG signaling in goat mammary epithelial cells

Animal Research and One Health, EarlyView.
In this study, it revealed that TRIB3 could mediate the transcriptional activity of PPARG, inhibit the phosphorylation of akt, and reduce the expression of lipid metabolism‐related genes, thus inhibiting TAG synthesis and affecting fatty acid composition.
Xinglong Gong, Tan Pan, Tiantian Xiong, Yifan Zhu, Juan J. Loor, Chengming Han, Yifan Li, Huan Lei, Jun Luo, Cong Li   +9 more
wiley   +1 more source

The effect and underlying mechanisms of titanium dioxide nanoparticles on glucose homeostasis: A literature review

Journal of Applied Toxicology, Volume 43, Issue 1, Page 22-31, January 2023., 2023
Abstract Titanium dioxide (TiO2) is used extensively as a white pigment in the food industry, personal care, and a variety of products of everyday use. Although TiO2 has been categorized as a bioinert material, recent evidence has demonstrated different toxicity profiles of TiO2 nanoparticles (NPs) and a potential health risk to humans.
Vida Mohammadparast, Beth L. Mallard
wiley   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Activation of serine/threonine protein kinases and early growth response 1 gene expression by tumor necrosis factor in human myeloid leukemia cells. [PDF]

, 1995
Ahamed Saleem, Zhiming Yuan, Neelam Taneja, Ethel Rubin, D Kufe, Surender Kharbanda   +5 more
openalex   +1 more source

Advances in Cancer Therapy: A Comprehensive Review of CDK and EGFR Inhibitors

Cells
Protein kinases have essential responsibilities in controlling several cellular processes, and their abnormal regulation is strongly related to the development of cancer.
Mohammed Hawash
doaj   +1 more source

SAGEPhos: Sage Bio-Coupled and Augmented Fusion for Phosphorylation Site Detection [PDF]

arXiv
Phosphorylation site prediction based on kinase-substrate interaction plays a vital role in understanding cellular signaling pathways and disease mechanisms. Computational methods for this task can be categorized into kinase-family-focused and individual kinase-targeted approaches.
arxiv  

TheMycobacterium bovishomologous protein of theMycobacterium tuberculosisserine/threonine protein kinase Mbk (PknD) is truncated [PDF]

, 2000
Priska Peirs, B. Parmentier, Luk De Wit, J. Content   +3 more
openalex   +1 more source

β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf [PDF]

, 2000
John Schmitt, Philip A. Stork
openalex   +1 more source

Long noncoding RNA CDKN2B‐AS1 silencing protects against esophageal cancer cell invasion and migration by inactivating the TFAP2A/FSCN1 axis

The Kaohsiung Journal of Medical Sciences, Volume 38, Issue 12, Page 1144-1154, December 2022., 2022
Abstract Esophageal cancer (EC) is the most aggressive malignancy in the gastrointestinal tract. Long noncoding RNA cyclin‐dependent kinase inhibitor 2 B antisense RNA 1 (CDKN2B‐AS1) is implicated in EC development. However, the specific mechanisms involved remain poorly defined.
Jia‐Liang Zhu, Wen‐Bo Xue, Zhi‐Bin Jiang, Wei Feng, Yi‐Cai Liu, Xiong‐Ying Nie, Long‐Yu Jin   +6 more
wiley   +1 more source

Rapid stimulation by insulin of a serine/threonine kinase in 3T3-L1 adipocytes that phosphorylates microtubule-associated protein 2 in vitro.

, 1987
L. Bryan Ray, T W Sturgill
openalex   +1 more source