Results 151 to 160 of about 3,595,860 (302)

Crosstalk between protein kinases Pho85-Pho80 and Rim11 regulates Pah1 phosphatidate phosphatase function in lipid synthesis. [PDF]

J Biol Chem
Khondker S, Bostrom ER, Carmon T, Hu KS, Privalov A, Han GS, Carman GM.   +6 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

[Expression of Concern] RIP kinase‑mediated ROS production triggers XAF1 expression through activation of TAp73 in casticin‑treated bladder cancer cells. [PDF]

Oncol Rep
Chung YH, Kim D.
europepmc   +1 more source

Serine/Threonine-Protein Kinase ULK1 [PDF]

, 2020
openaire   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Phylogeny and Expansion of Serine/Threonine Kinases in Phagocytotic Bacteria in the Phylum Planctomycetota

The recently isolated bacterium "Candidatus Uabimicrobium amorphum" is the only known prokaryote that can engulf other bacterial cells. Its proteome contains a high fraction of proteins involved in signal transduction systems, which is a feature normally
Andersson, Siv G. E., Andersson, Siv G. E.,, Odelgard, Anna, Guy, Lionel,, Hägglund, Emil, Hägglund, Emil,, Odelgard, Anna,, Guy, Lionel   +7 more
core   +1 more source

A complex of MAST1 and 14-3-3η regulates Tau phosphorylation in the developing cortex. [PDF]

Proc Natl Acad Sci U S A
Antonioli S, Heisterkamp P, Chen W, Anrather D, Hartl M, Martinez-Reza MF, Tripathy R, Schutzbier M, Mechtler K, Keays DA, Leonard TA.   +10 more
europepmc   +1 more source

Serine/Threonine-Protein Kinase Sgk1 [PDF]

, 2020
openaire   +1 more source

z‐VAD‐FMK triggers macrophage necroptosis during mycobacterial infection via a non‐canonical off‐target mechanism

mLife, EarlyView.
Abstract Macrophages are the predominant cell type infected by Mycobacterium tuberculosis (Mtb) in tuberculosis (TB). Death of Mtb‐infected macrophages promotes tissue pathology and releases Mtb to infect other cells, suggesting that inhibiting the death of Mtb‐infected macrophages could be an adjunctive treatment of TB.
Rong Hu, Pei Li, Jie Han, Jiamin Huang, Guoyi Huang, Xiuju Jiang, Daniel Pfau, Guobao Li, Yi‐Nan Gong, Carl F. Nathan, Li Zhang   +10 more
wiley   +1 more source

Recent medicinal chemistry efforts of targeting protein kinases for treating neurological conditions of Parkinson's and Alzheimer's diseases. [PDF]

RSC Adv
Kaur R, Lang DK, Sood A, Singh TG, Chandrasekaran B, Al-Sha'er MA.   +5 more
europepmc   +1 more source