Results 181 to 190 of about 212,467 (329)

TRIB3 suppresses milk fatty acids metabolism by inhibiting p‐AKT/PPARG signaling in goat mammary epithelial cells

Animal Research and One Health, EarlyView.
In this study, it revealed that TRIB3 could mediate the transcriptional activity of PPARG, inhibit the phosphorylation of akt, and reduce the expression of lipid metabolism‐related genes, thus inhibiting TAG synthesis and affecting fatty acid composition.
Xinglong Gong, Tan Pan, Tiantian Xiong, Yifan Zhu, Juan J. Loor, Chengming Han, Yifan Li, Huan Lei, Jun Luo, Cong Li   +9 more
wiley   +1 more source

The Link Between TGF‐β Signaling and Chromatin Dynamics Takes an Unexpected Path

BioEssays, EarlyView.
A recent study uncovered a novel mechanism by which Tgfbr1 regulates morphogenesis: not by directly controlling the expression of genes regulating cell fate but by globally modulating chromatin accessibility, thus determining which enhancers are available to other morphogenetic factors, ultimately enabling the activation of specific developmental ...
Moises Mallo
wiley   +1 more source

Dynamic protein interactions probed by NMR spectroscopy

Bulletin of the Korean Chemical Society, EarlyView.
Abstract Dynamic protein–protein interactions are essential for diverse cellular processes but often evade structural characterization due to their transient, heterogeneous, and disordered nature. This review focuses on how nuclear magnetic resonance (NMR) spectroscopy can provide detailed, residue‐level insights into these complex interactions.
Jaeseok Lee, Jung Ho Lee
wiley   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

Promising Prodiginins Biological Activities

Chemistry &Biodiversity, EarlyView.
ABSTRACT Prodiginins are a large family of at least 34 pyrrolic compounds, including the well‐studied red pigment prodigiosin. Prodiginins are produced by several microorganisms displaying broad biological activities, including antimicrobial, antiviral, antiparasitic, antiproliferative, and immunosuppressive activities.
María F. Ladetto, Melisa E. Gantner, Boris E. Rodenak‐Kladniew, Santiago Rodriguez, María L. Cuestas, Alan Talevi, Guillermo R. Castro   +6 more
wiley   +1 more source

Citrus Flavonoids as Antimicrobials

Chemistry &Biodiversity, EarlyView.
Citrus flavonoids are powerful and versatile antimicrobials whose mechanism of action often involves disruption of the bacterial membrane, thereby minimizing antimicrobial resistance. This study provides a unified perspective. ABSTRACT Citrus flavonoids are highly bioactive compounds exerting numerous health benefits including anticancer, antioxidant ...
Rosaria Ciriminna, Giovanna Li Petri, Giuseppe Angellotti, Rafael Luque, Anne‐Sylvie Fabiano Tixier, Francesco Meneguzzo, Mario Pagliaro   +6 more
wiley   +1 more source

Proteomic surveys of the mouse heart unveil cardiovascular responses to nitric oxide/cGMP signaling deficiencies. [PDF]

Commun Biol
Mohanty I, Fazelinia H, Raimo S, Ding H, Spruce L, Symeonidou M, Tenopoulou M, Ichinose F, Yamashita H, Shimokawa H, Masato T, Doulias PT, Ischiropoulos H.   +12 more
europepmc   +1 more source

A tailored phospho‐p53 library probes antibody specificity and recognition limitations

ChemBioChem, Accepted Article.
The tumour suppressor protein p53, known as the "guardian of the genome", is regulated by a complex network of posttranslational modifications (PTMs). Phosphorylations at 7 Ser/Thr residues within the N‐terminal transactivation domain 1 (TAD1) play a role in p53 activation, yet their precise mechanisms of action remain elusive due to challenges in ...
Mateusz Hess, Jonathan Davies, Sofia Margiola, Sonja Schneider, Thomas Hicks, Nishant Rai, Manuel Martin Müller   +6 more
wiley   +1 more source

Evolution and classification of Ser/Thr phosphatase PP2C family in bacteria: Sequence conservation, structures, domain distribution. [PDF]

PLoS One
Li H, Li R, Yu H, Zhang Y, Feng H.
europepmc   +1 more source