Results 261 to 270 of about 212,467 (329)

A stress-responsive p38 signaling axis in choanoflagellates. [PDF]

RSC Chem Biol
Rutaganira FU, Coyle MC, Nguyen MHT, Hernandez I, Scopton AP, Dar AC, King N.   +6 more
europepmc   +1 more source

Phosphorylation Changes SARS‐CoV‐2 Nucleocapsid Protein's Structural Dynamics and Its Interaction With RNA

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The SARS‐CoV‐2 nucleocapsid protein, or N‐protein, is a structural protein that plays an important role in the SARS‐CoV‐2 life cycle. The N‐protein takes part in the regulation of viral RNA replication and drives highly specific packaging of full‐length genomic RNA prior to virion formation.
Stefan Loonen, Lina van Steenis, Marianne Bauer, Nikolina Šoštarić   +3 more
wiley   +1 more source

KINAID: an orthology-based kinase-substrate prediction and analysis tool for phosphoproteomics. [PDF]

Bioinformatics
Aman JM, Zhu AW, Wühr M, Shvartsman SY, Singh M.   +4 more
europepmc   +1 more source

Liposome‐Polymer Nanoparticles Loaded with Copper Diethyldithiocarbamate and 6‐Bromo‐Indirubin‐3′‐Oxime Enable the Treatment of Refractive Melanoma

Small, EarlyView.
Cancer cells are exposed to heightened levels of endoplasmic reticulum stress and inflammation within the tumor microenvironment which can lead to therapeutic resistance. To address this issue, liposome‐polymer nanoparticles loaded with copper diethyldithiocarbamate (CuET), a potent inhibitor of the p97‐UFD1‐NPL4 protein complex, and the anti ...
Radu A. Paun, Ling Li, Adam Mouncef, Danuta Radzioch, Maryam Tabrizian   +4 more
wiley   +1 more source

PIM kinase control of CD8 T cell protein synthesis and cell trafficking. [PDF]

Elife
Marchingo JM, Spinelli L, Pathak S, Cantrell DA.   +3 more
europepmc   +1 more source

Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy

Small Science, EarlyView.
Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri, Rodolfo Villa, Ya‐Ping Shiau, Menghuan Tang, Kelsey Jane Racacho, Qiufang Zong, Saiful Islam Chowdhury, Tan Hua, Felipe Godinez, Andrew Birkeland, Tzu‐Yin Lin, Yuanpei Li   +11 more
wiley   +1 more source

Molecular mechanisms and consequences of TDP-43 phosphorylation in neurodegeneration. [PDF]

Mol Neurodegener
Kellett EA, Bademosi AT, Walker AK.
europepmc   +1 more source

Native Taylor/Non‐Taylor Dispersion–Mass Spectrometry (TNT‐MS) Allows Rapid Protein Desalting and Multiplexed, Label‐Free Ligand Screening

Small Methods, EarlyView.
Native mass spectrometry enables the label‐free study of noncovalent protein‐ligand complexes; however, it is incompatible with conventional molecular biology buffers. By exploiting the dependence of flow dynamics on the hydrodynamic radius, proteins are seperated, including protein‐ligand complexes, from non‐volatile salts and unbound small molecules ...
Jonathan Eisert, Edvaldo Vasconcelos Soares Maciel, Verena Dederer, Aylin Berwanger, Henry J. Bailey, Ivan Đikić, Stefan Knapp, Martin Empting, Sebastian Mathea, Henrik Jensen, Frederik Lermyte   +10 more
wiley   +1 more source

Role of Tyrosine Phosphorylation in PEP1 Receptor 1(PEPR1) in <i>Arabidopsis thaliana</i>. [PDF]

Plants (Basel)
Choi JH, Oh MH.
europepmc   +1 more source

Frog‐Derived Neuroregenerative‐Peptide‐Reinforced Bioactive Hydrogels with Injectability, Thermosensitivity, and Enhanced Neurotrophic Function for Repairing Central Nervous Injuries

Small Structures, EarlyView.
Herein, the reinforcement of bioactive hydrogels with frog‐derived neuroregenerative peptide (FRNP) is presented to create multifunctional materials with injectability, thermosensitivity, and neurorepair capabilities. The formation of a porous, dual‐network hydrogel structure, combined with the action of FRNP, promotes the proliferation, migration, and
Zhengang Sun, Zhenjuan Sun, Chenxi Du, Hongyu Chen, Xingchao Zhang, Yuanyuan Liu, Fang Dong, Xuexiao Ma, Gang Wei, Haiyuan Yue   +9 more
wiley   +1 more source