Results 261 to 270 of about 133,461 (307)

Recent advances in bacterial signaling by serine/threonine protein kinases

Trends in Microbiology, 2022
It has been nearly three decades since the discovery of the first bacterial serine/threonine protein kinase (STPK). Since then, a blend of technological advances has led to the characterization of a multitude of STPKs and phosphorylation substrates in several bacterial species that finely regulate intricate signaling cascades. Years of intense research
Sathya Narayanan Nagarajan, Cassandra Lenoir, Christophe Grangeasse   +2 more
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Serine/Threonine Protein Kinases and Phosphatases in Filamentious Fungi

Fungal Genetics and Biology, 1999
Protein phosphorylation and dephosphorylation are one of the central currencies by which living cells perceive and respond to environmental cues. A number of fundamental processes in fungi such as the cell cycle, transcription, and mating have been shown to require protein phosphorylation. The analysis of protein kinases and phosphatases in filamentous
Oded Yarden, Martin B. Dickman
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Serine threonine protein kinases of mycobacterial genus: phylogeny to function [PDF]

Physiological Genomics, 2007
Serine/threonine protein kinases (STPKs) are known to act as sensors of environmental signals that thereby regulate developmental changes and host pathogen interactions. In this study, we carried out comparative genome analysis of six completely sequenced pathogenic and nonpathogenic mycobacterial species to systematically characterize the STPK ...
Anil K. Tyagi, Yogendra Singh, Azeet Narayan, Adesh K. Saini, Preeti Sachdeva, Kirti Sharma   +5 more
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Protein Serine/Threonine Kinases

2000
The reversible phosphorylation of proteins by protein kinases is the most extensively used molecular mechanism regulating cellular functions in eukaryotes. Essentially all major cellular processes, including cell growth and differentiation, motility, metabolism, and communication between cells, are in some way regulated by protein phosphorylation (Fig.
Heierhorst, Jorg, Pearson, Richard, Horne, James, Bozinovski, Steven, Kobe, Bostjan, Kemp, Bruce E.   +5 more
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Identification and characterization of the serine/threonine protein kinases in Bifidobacterium

Archives of Microbiology, 2014
Six genes encoding the bifidobacterial Hanks-type (eukaryote-like) serine/threonine protein kinases (STPK) were identified and classified. The genome of each bifidobacterial strain contains four conserved genes and one species-specific gene. Bifidobacterium longum and Bifidobacterium bifidum possess the unique gene found only in these species. The STPK
Natalia V. Zakharevich, M. G. Alekseeva, Olga V. Averina, Valery N. Danilenko, D. A. Mavletova, V. Z. Nezametdinova   +5 more
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Synthetic sulfoglycolipids targeting the serine–threonine protein kinase Akt

Bioorganic & Medicinal Chemistry, 2016
The serine-threonine protein kinase Akt, also known as protein kinase B, is a key component of the phosphoinositide 3-kinase (PI3K)-Akt-mTOR axis. Deregulated activation of this pathway is frequent in human tumors and Akt-dependent signaling appears to be critical in cell survival.
COSTA, BARBARA SIMONA, DANGATE, MILIND, Vetro, M, DONVITO, GIULIA, GABRIELLI, LUCA, AMIGONI, LOREDANA, Cassinelli, G, Lanzi, C, CERIANI, MICHELA, DE GIOIA, LUCA, FILIPPI, GIULIA, CIPOLLA, LAURA FRANCESCA, Zaffaroni, N, Perego, P, Colombo, D.   +14 more
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Serine-Threonine Protein Kinases of Cyanobacteria

Biochemistry (Moscow)
Protein phosphorylation is a pivotal mechanism for signal transduction, regulation of biochemical processes essential for reproduction, growth, and adaptation of organisms to changing conditions. Bacteria, which emerged more than 3.5 billion years ago, faced the need to adapt to a variety of ecological niches from the very beginning of their existence.
Anna A, Zorina, Dmitry A, Los, Oleg I, Klychnikov   +2 more
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Protein-serine/threonine/tyrosine kinases in bacterial signaling and regulation

FEMS Microbiology Letters, 2013
In this review, we address some recent developments in the field of bacterial protein phosphorylation, focusing specifically on serine/threonine and tyrosine kinases. We present an overview of recent studies outlining the scope of physiological processes that are regulated by phosphorylation, ranging from cell cycle, growth, cell morphology, to ...
Ivan Mijakovic, Ivan Mijakovic, Ivan Mijakovic, Charlotte Cousin, Lei Shi, Yves Pagot, Yves Pagot, Sandrine Poncet, Abderahmane Derouiche   +8 more
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Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

Science, 1997
A signaling pathway was delineated by which insulin-like growth factor 1 (IGF-1) promotes the survival of cerebellar neurons. IGF-1 activation of phosphoinositide 3-kinase (PI3-K) triggered the activation of two protein kinases, the serine-threonine kinase Akt and the p70 ribosomal protein S6 kinase (p70 S6K ...
Morris J. Birnbaum, Thomas F. Franke, Ryoji Yao, Michael E. Greenberg, Rosalind A. Segal, David R. Kaplan, Henryk Dudek, Geoffrey M. Cooper, Sandeep Robert Datta   +8 more
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PLANT PROTEIN SERINE/THREONINE KINASES: Classification and Functions

Annual Review of Plant Physiology and Plant Molecular Biology, 1999
▪ Abstract  The first plant protein kinase sequences were reported as recently as 1989, but by mid-1998 there were more than 500, including 175 in Arabidopsis thaliana alone. Despite this impressive pace of discovery, progress in understanding the detailed functions of protein kinases in plants has been slower. Protein serine/threonine kinases from A.
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