Results 261 to 270 of about 142,215 (332)

The Effect and Treatment of PIK3CA Mutations in Breast Cancer: Current Understanding and Future Directions. [PDF]

Medicina (Kaunas)
Cho YB, Park KS.
europepmc   +1 more source

Multifunctional Co‐Delivery Systems with Downregulation of the Novel Target PIM1 in Macrophages to Ameliorate TF‐Mediated Coagulopathy in Sepsis

Small, EarlyView.
PIM1 is screened out and verified its correlation with sepsis‐induced coagulopathy by bioinformatic analysis and clinical research. Then a multifunctional co‐delivery system (MPDA@PEI@GM) is proposed for the co‐deliver of the PIM1 inhibitors SMI‐4a and small interfering RNA (siPIM1) to reduce PIM1 expression, which effectively inhibits the expression ...
Aiming Zhou, Jiejie Cai, Ying Wang, Rongrong Zhang, Jiang Tan, Chen Zhou, Shuang Luo, Qiuqi Gao, Yueyue Huang, Yihua Dong, Haiqing Song, Jingye Pan   +11 more
wiley   +1 more source

Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy

Small Science, EarlyView.
Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri, Rodolfo Villa, Ya‐Ping Shiau, Menghuan Tang, Kelsey Jane Racacho, Qiufang Zong, Saiful Islam Chowdhury, Tan Hua, Felipe Godinez, Andrew Birkeland, Tzu‐Yin Lin, Yuanpei Li   +11 more
wiley   +1 more source

Multi-Omic Evaluation of PLK1 Inhibitor-Onvansertib-In Colorectal Cancer Spheroids. [PDF]

J Mass Spectrom
Fries BD, Sekera ER, Holbrook JH, Hummon AB.   +3 more
europepmc   +1 more source

Frog‐Derived Neuroregenerative‐Peptide‐Reinforced Bioactive Hydrogels with Injectability, Thermosensitivity, and Enhanced Neurotrophic Function for Repairing Central Nervous Injuries

Small Structures, EarlyView.
Herein, the reinforcement of bioactive hydrogels with frog‐derived neuroregenerative peptide (FRNP) is presented to create multifunctional materials with injectability, thermosensitivity, and neurorepair capabilities. The formation of a porous, dual‐network hydrogel structure, combined with the action of FRNP, promotes the proliferation, migration, and
Zhengang Sun, Zhenjuan Sun, Chenxi Du, Hongyu Chen, Xingchao Zhang, Yuanyuan Liu, Fang Dong, Xuexiao Ma, Gang Wei, Haiyuan Yue   +9 more
wiley   +1 more source

Troglitazone Reduction of Intracellular Mycobacterium tuberculosis Survival Via Macrophage Autophagy Through LKB1-AMPKα Signaling. [PDF]

J Infect Dis
Bi J, Guo Q, Gong Y, Chen X, Wu H, Song L, Xu Y, Ou M, Wang Z, Chen J, Jiang C, Liu A, Li G, Zhang G.   +13 more
europepmc   +1 more source

Eeukaryotic-like Sppsk1 from Vibrio splendidus AJ01 mediates phagosome escape via inhibiting phagosome acidification and maturation. [PDF]

Cell Mol Life Sci
Dai F, Liang W, Liu J, Guo M, Li C.
europepmc   +1 more source

Effector proteins of Funneliformis mosseae BR221: unravelling plant-fungal interactions through reference-based transcriptome analysis, in vitro validation, and protein‒protein docking studies. [PDF]

BMC Genomics
Vasistha P, Singh PP, Srivastava D, Johny L, Shukla S.   +4 more
europepmc   +1 more source

TaSnRK3.23B, a CBL-interacting protein kinase of wheat, confers drought stress tolerance by promoting ROS scavenging in Arabidopsis. [PDF]

BMC Plant Biol
Dong F, Liu Y, Zhang H, Li Y, Song J, Chen S, Wang S, Zhu Z, Li Y, Liu Y.   +9 more
europepmc   +1 more source