Results 41 to 50 of about 220,067 (314)

ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve

iScience, 2022
Summary: Cells elaborate transcriptional programs in response to external signals. In the peripheral nerves, Schwann cells (SC) sort axons of given caliber and start the process of wrapping their membrane around them.
Hye-Jin Park, Eric Tsai, Dennis Huang, Michael Weaver, Luciana Frick, Ace Alcantara, John J. Moran, Julia Patzig, Carmen V. Melendez-Vasquez, Gerald R. Crabtree, M.L. Feltri, John Svaren, Patrizia Casaccia   +12 more
doaj   +1 more source

PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity [PDF]

, 2016
The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos between membranes. The cargo sorting mechanism between cilia and other compartments is not understood.
Fansa, Eyad Kalawy, Ismail, Shehab, Kösling, Stefanie Kristine, Wittinghofer, Alfred, Zent, Eldar   +4 more
core   +1 more source

Cell wall sorting signals in surface proteins of gram-positive bacteria. [PDF]

The EMBO Journal, 1993
Staphylococcal protein A is anchored to the cell wall, a unique cellular compartment of Gram-positive bacteria. The sorting signal sufficient for cell wall anchoring consists of an LPXTG motif, a C-terminal hydrophobic domain and a charged tail. Homologous sequences are found in many surface proteins of Gram-positive bacteria and we explored the ...
O, Schneewind, D, Mihaylova-Petkov, P, Model   +2 more
openaire   +2 more sources

Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.

PLoS ONE, 2013
CALM (clathrin assembly lymphoid myeloid leukemia protein) is a cargo-selective adaptor for the post-Golgi R-SNAREs VAMPs 2, 3, and 8, and it also regulates the size of clathrin-coated pits and vesicles at the plasma membrane.
Daniela A Sahlender, Patrycja Kozik, Sharon E Miller, Andrew A Peden, Margaret S Robinson   +4 more
doaj   +1 more source

VGLUT2 Trafficking Is Differentially Regulated by Adaptor Proteins AP-1 and AP-3

Frontiers in Cellular Neuroscience, 2017
Release of the major excitatory neurotransmitter glutamate by synaptic vesicle exocytosis depends on glutamate loading into synaptic vesicles by vesicular glutamate transporters (VGLUTs).
Haiyan Li, Magda S. Santos, Chihyung K. Park, Yuriy Dobry, Susan M. Voglmaier   +4 more
doaj   +1 more source

SARS-CoV-2 spike host cell surface exposure promoted by a COPI sorting inhibitor

Acta Pharmaceutica Sinica B, 2023
Via an insufficient coat protein complex I (COPI) retrieval signal, the majority of SARS-CoV-2 spike (S) is resident in host early secretory organelles and a tiny amount is leaked out in cell surface.
Yiqun Li, Mingrui Yang, Yanan Nan, Jiaming Wang, Sanjiao Wang, Dongxiao Cui, Jiajian Guo, Pengfei He, Wenxin Dai, Shuqi Zhou, Yue Zhang, Wenfu Ma   +11 more
doaj   +1 more source

Convolutional LSTM Networks for Subcellular Localization of Proteins [PDF]

, 2015
Machine learning is widely used to analyze biological sequence data. Non-sequential models such as SVMs or feed-forward neural networks are often used although they have no natural way of handling sequences of varying length.
A Graves, A Höglund, A Prlić, C Magnan, G Dahl, HY Xiong, LJP Maaten Van Der, M Schuster, MCF Thomsen, O Emanuelsson, P Baldi, P Lena Di, S Briesemeister, S Henikoff, S Hochreiter, SF Altschul, T Blum, T Goldberg, T Petersen, Y Bengio   +19 more
core   +3 more sources

A new class of lysosomal/vacuolar protein sorting signals.

Journal of Biological Chemistry, 1990
A number of inherited lysosomal diseases are known to result from missorting of lysosomal proteins. Considerable attention has been directed toward an understanding of this sorting pathway, and it has become apparent that different mechanisms are used for the sorting of lysosomal membrane and soluble proteins.
D J, Klionsky, S D, Emr
openaire   +2 more sources

A bipartite sorting signal ensures specificity of retromer complex in membrane protein recycling [PDF]

Journal of Cell Biology, 2019
Retromer is an evolutionarily conserved protein complex, which sorts functionally diverse membrane proteins into recycling tubules/vesicles from the endosome. Many of the identified cargos possess a recycling signal sequence defined as ØX[L/M/V], where Ø is F/Y/W. However, this sequence is present in almost all proteins encoded in the genome.
Sho W. Suzuki, Ya-Shan Chuang, Ming Li, Matthew N.J. Seaman, Scott D. Emr   +4 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source