Results 61 to 70 of about 4,545,906 (256)

The Prion-like domain in the exomer-dependent cargo Pin2 serves as a trans-Golgi retention motif [PDF]

, 2014
Prion and prion-like domains (PLDs) are found in many proteins throughout the animal kingdom. We found that the PLD in the S. cerevisiae exomer-depen- dent cargo protein Pin2 is involved in the regulation of protein transport and localization. The domain
Ritz, Alicja M., Mark Trautwein, Trautwein, Mark, Anne Spang, Spang, Anne, Grassinger, Franziska, Alicja M. Ritz, Franziska Grassinger, Ritz, A. M., Grassinger, F., Spang, A., Trautwein, M.   +11 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

An ultrasensitive sorting mechanism for EGF receptor endocytosis [PDF]

, 2008
Background The EGF receptor has been shown to internalize via clathrin-independent endocytosis (CIE) in a ligand concentration dependent manner. From a modeling point of view, this resembles an ultrasensitive response, which is the ability of signaling ...
Roland Eils, Hoeller, Daniela, Ivayla Vacheva, Schmidt-Glenewinkel, Hannah, Eils, Roland, Hannah Schmidt-Glenewinkel, Đikić, Ivan, Vacheva, Ivayla, Daniela Hoeller, Ivan Dikic   +9 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17 [PDF]

Nature Communications, 2015
The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release are poorly understood.
Dombernowsky, Sarah Louise, Samsøe-Petersen, Jacob, Petersen, Camilla Hansson, Instrell, Rachael, Hedegaard, Anne-Mette Bornhardt, Thomas, Laurel, Atkins, Katelyn Mae, Auclair, Sylvain, Albrechtsen, Reidar, Mygind, Kasper Johansen, Fröhlich, Camilla, Howell, Michael, Parker, Peter, Thomas, Gary, Kveiborg, Marie   +14 more
openaire   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Bicomponent sorting algorithms

, 2023
The possibilities of improving sorting time parameters through preprocessing by stochastic sorting were investigated. The hypothesis that two-component stochastic + classical sorting outperforms classic one-component sorting in terms of time efficiency ...
Halanin, K. K., Yatsenko, O. A., Shynkarenko, V. I., Doroshenko, A. Yu., Raznosilin, V. V.   +4 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Clostridium difficile has a single sortase, SrtB, that can be inhibited by small-molecule inhibitors. [PDF]

, 2014
BACKGROUND: Bacterial sortases are transpeptidases that covalently anchor surface proteins to the peptidoglycan of the Gram-positive cell wall. Sortase protein anchoring is mediated by a conserved cell wall sorting signal on the anchored protein ...
Valiente, Esmeralda, Donahue, Elizabeth H, Major, Meriel R, Perrior, Trevor R, Firth-Clark, Stuart, Dawson, Lisa F, Littler, Eddy, Wren, Brendan W   +7 more
core   +1 more source