Results 81 to 90 of about 4,545,906 (256)

Bacterial porin disrupts mitochondrial membrane potential and sensitizes host cells to apoptosis [PDF]

, 2009
The bacterial PorB porin, an ATP-binding beta-barrel protein of pathogenic Neisseria gonorrhoeae, triggers host cell apoptosis by an unknown mechanism. PorB is targeted to and imported by host cell mitochondria, causing the breakdown of the mitochondrial
Kepp, Oliver, Meinecke, M., Harsman, Anke, Meinecke, Michael, Joachim Rassow, Hauf, Eva, Kepp, O., Günther, Dirk, Oliver Kepp, Richard Wagner, Dirk Günther, Thomas Rudel, Hauf, E., Wagner, R., Katharina Ross, Rassow, Joachim, Volker Brinkmann, Brinkmann, Volker, Rajalingam, Krishnaraj, Ines Herrmann, Elke A. Dian-Lothrop, Brinkmann, V., Kozjak-Pavlovic, V., Günther, D., Kozjak-Pavlovic, Vera, Ross, Katharina, Eva Hauf, Vera Kozjak-Pavlovic, Michael Meinecke, Robert Hurwitz, Dian-Lothrop, E., Wagner, Richard, Ross, K., Rajalingam, K., Rudel, T., Dian-Lothrop, Elke A., Rudel, Thomas, Hurwitz, Robert, Krishnaraj Rajalingam, Harsman, A., Elke A Dian-Lothrop, Herrmann, I., Hurwitz, R., Herrmann, Ines, Rassow, J., Anke Harsman   +45 more
core   +2 more sources

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Glycosylation pattern of brush border-associated glycoproteins in enterocyte-like cells: involvement of complex-type N-glycans in apical trafficking [PDF]

, 2009
We have previously reported that galectin-4, a tandem repeat-type galectin, regulates the raft-dependent delivery of glycoproteins to the apical brush border membrane of enterocyte-like HT-29 cells.
Huet, Guillemette, Stechly, Laurence, André, Sabine, Seuningen, Isabelle Van, van Seuningen, Isabelle, Gabius, Hans-Joachim, Morelle, Willy, Michalski, Jean-Claude, Porchet, Nicole   +8 more
core   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

NcPred for accurate nuclear protein prediction using n-mer statistics with various classification algorithms [PDF]

, 2011
Prediction of nuclear proteins is one of the major challenges in genome annotation. A method, NcPred is described, for predicting nuclear proteins with higher accuracy exploiting n-mer statistics with different classification algorithms namely ...
Alaol Kabir, Kabir, Alaol, Sakib, Kazi, Kazi Sakib, Hossain, Alamgir, Islam, Md Saiful, Islam, Md. Saiful, Hossain, Md Alamgir, Md. Alamgir Hossain, Md. Saiful Islam   +9 more
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

iLIR : a web resource for prediction of Atg8-family interacting proteins [PDF]

, 2014
Macroautophagy was initially considered to be a nonselective process for bulk breakdown of cytosolic material. However, recent evidence points toward a selective mode of autophagy mediated by the so-called selective autophagy receptors (SARs).
Nezis, I. P., Osgood, Richard, Mulakkal, Nitha Charles, Promponas, Vasilis J., Kalvari, Ioanna, Johansen, Terje, Tsompanis, Stelios   +6 more
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

HIV and SIV Nef Modulate Signal Transduction and Protein Sorting in T Cells

Cold Spring Harbor Symposia on Quantitative Biology, 1999
One striking aspect of immunodeficiency viruses istheir ability to replicate and maintain persistent infectionin the face of the host immune response and to eventuallyovercome this response (Desrosiers 1999). The progressive loss of CD4+ T lymphocytes, the hallmark of AIDSinfection, reflects the host's inability to regenerate thesecells as ...
J, Skowronski, M E, Greenberg, M, Lock, R, Mariani, S, Salghetti, T, Swigut, A J, Iafrate   +6 more
openaire   +2 more sources