Results 71 to 80 of about 4,545,906 (256)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Identification and characterization of Syndapin I, Vacuolar protein sorting 35 and Neurobeachin as new interaction partners of the glycine receptor [PDF]

, 2011
The glycine receptor (GlyR) is the major inhibitory neurotransmitter receptor in spinal cord and brainstem. Heteropentameric GlyRs are clustered and anchored at inhibitory postsynaptic sites by the binding of the large intracellular loop between ...
del Pino Pariente, I., Pino Pariente, Isabel del   +1 more
core  

Targeting of protein ERGIC-53 to the ER/ERGIC/cis-Golgi recycling pathway [PDF]

, 1995
ERGIC-53 is a lectin-type membrane protein that continuously recycles between the ER, ER-Golgi intermediate compartment (ERGIC) and the cis-Golgi. To identify the targeting signals that mediate this recycling, N-glycosylated and myc-tagged variants of ...
R Schindler, Itin, C., C Itin, Schindler, R., Hauri, H. P., H P Hauri   +5 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Nuclear Import and Export Signals of Human Cohesins SA1/STAG1 and SA2/STAG2 Expressed in Saccharomyces cerevisiae [PDF]

, 2012
Background: Human SA/STAG proteins, homologues of the yeast Irr1/Scc3 cohesin, are the least studied constituents of the sister chromatid cohesion complex crucial for proper chromosome segregation.
Jurek, Marta, Leszek J. Tarnowski (160129), Milewski Michał, Michał Milewski (160136), Milewski, Michał, Plochocka, Danuta, Kurlandzka, Anna, Anna Kurlandzka, Marta Jurek, Kowalec, Piotr, Tarnowski, Leszek J, Jan Fronk, Jurek Marta, Piotr Kowalec, Tarnowski Leszek J., Danuta Plochocka, Jan Fronk (160145), Kowalec Piotr, Fronk Jan, Plochocka Danuta, Piotr Kowalec (160133), Fronk, Jan, Leszek J Tarnowski, Michał Milewski, Marta Jurek (160140), Kurlandzka Anna, Anna Kurlandzka (160147), Danuta Plochocka (160143)   +27 more
core   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

The Beneficial Impact of Sorting Heavy Cattle at Re-Implant [PDF]

This research examined a simple sorting strategy to reduce the prevalence of heavyweight carcass discounts. Cattle that were identified and sorted off at re-implant had a reduced prevalence of heavyweight carcasses versus unsorted cattle.
Link, David J., Almas, Lal K., Brown, Michael S., Lawrence, Ty E.   +3 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

PAT1, a microtubule-interacting protein, recognizes the basolateral sorting signal of amyloid precursor protein

Proceedings of the National Academy of Sciences, 1998
In epithelial cells, sorting of membrane proteins to the basolateral surface depends on the presence of a ba solateral s orting s ignal (BaSS) in their cytoplasmic domain.
P, Zheng, J, Eastman, S, Vande Pol, S W, Pimplikar   +3 more
openaire   +3 more sources