Results 31 to 40 of about 4,545,906 (256)
Feature extraction using extrema sampling of discrete derivatives for spike sorting in implantable upper-limb neural prostheses [PDF]
, 2014 Next generation neural interfaces for upper-limb (and other) prostheses aim to develop implantable interfaces for one or more nerves, each interface having many neural signal channels that work reliably in the stump without harming the nerves. To achieve
Demosthenous, A +3 more
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JCI Insight, 2023 Glioblastoma is the most malignant primary brain tumor, the prognosis of which remains dismal even with aggressive surgical, medical, and radiation therapies. Glioblastoma stem cells (GSCs) promote therapeutic resistance and cellular heterogeneity due to their self-renewal properties and capacity for plasticity.
Ryan C. Gimple +19 more
openaire +3 more sources
The role of motor proteins in endosomal sorting [PDF]
, 2011 Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well as the transfer of material between them.
Hunt, Sylvie +3 more
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The characterization of adaptor protein homologues in Plasmodium falciparum [PDF]
, 2009 Includes abstract.Includes bibliographical references (leaves 148-171).Plasmodium falciparum is becoming increasingly more resistant to regular antimalarial drugs, making it necessary to identify novel drug candidates and drug targets.
Meredith, Sandra Allison
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Concepts of protein sorting or targeting signals and membrane topology in undergraduate teaching* [PDF]
Biochemistry and Molecular Biology Education, 2005 AbstractThe process of protein biogenesis culminates in its correct targeting to specific subcellular locations where it serves a function. Contemporary molecular and cell biology investigations often involve the exogenous expression of epitope‐ or fluorescent protein‐tagged recombinant molecules as well as subsequent analysis of protein‐protein ...
Bor Luen, Tang, Felicia Yu Hsuan, Teng
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N‐glycans are not a universal signal for apical sorting of secretory proteins
FEBS Letters, 1999 In MDCK cells, N‐glycans have been shown to determine the sorting of secretory proteins and membrane proteins to the apical domain in the absence of a dominant basolateral targeting signal. We have examined the sorting of endogenous proteins in ECV304 cells in the presence and absence of tunicamycin, an inhibitor of N‐linked glycosylation.
Su, Tao, Cariappa, Rohit, Stanley, Keith
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A di‐leucine sorting signal in ZIP1 (SLC39A1) mediates endocytosis of the protein [PDF]
The FEBS Journal, 2007 It has been demonstrated that the plasma membrane expression of ZIP1 is regulated by endocytic mechanisms. In the zinc‐replete condition, the level of surface expressed ZIP1 is low due to the rapid internalization of ZIP1. The present study aimed to identify a sorting signal(s) in ZIP1 that mediated endocytosis of ZIP1.
Huang, Liping, Kirschke, Catherine P
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FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
BayesMotif: de novo protein sorting motif discovery from impure datasets [PDF]
, 2010 Background Protein sorting is the process that newly synthesized proteins are transported to their target locations within or outside of the cell. This process is precisely regulated by protein sorting signals in different forms.
Zhang, F. +3 more
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source