Results 241 to 250 of about 10,358,150 (287)

Evolution and the Tertiary Structure of Proteins

Annual Review of Biophysics and Bioengineering, 1984
The fact that biological information is stored in the form of DNA has led some molecular biologists and biophysicists to the view that evolutionary history will be most evident in DNA sequences. This view is attractive, for there is a redundancy in the genetic code, and the number of base changes is a sensitive indicator of evolutionary distances ...
M, Bajaj, T, Blundell
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Protein Tertiary Structure Prediction

Current Protocols in Protein Science, 2000
AbstractThis unit addresses how to predict the tertiary structure of a protein from its amino acid sequence using computational methods. Three types of prediction methods‐‐homology modeling, fold recognition, and ab initio prediction‐‐are introduced.
D, Xu, Y, Xu
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Protein Tertiary Structure Modeling

Current Protocols in Protein Science, 2001
AbstractInsights into the 3D‐structure of a protein have proven useful during experiment design. Experimentally elucidated structures are often not available, but comparative protein modeling provides a viable alternative in many cases. This unit presents comparative protein modeling and how to use the highly sophisticated but easy‐to‐use free software
Guex, N., Schwede, T., Peitsch, M. C.
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Calculation of protein tertiary structure

Journal of Molecular Biology, 1976
Abstract We describe a method for calculating the tertiary structure of proteins given their amino acid sequence. The algorithm involves locally minimizing an energylike expression as a function of the Cartesian co-ordinates of the C β of all residues.
I D, Kuntz, G M, Crippen, P A, Kollman, D, Kimelman   +3 more
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Unfolding of tertiary structures of proteins

International Journal of Peptide and Protein Research, 1984
The unfolding pathway of lysozyme was investigated by carrying out the computer simulation. Taking into account the simultaneous change of both the dihedral angles ø and of a residue, we explore the detailed features of the conformational energy profiles. The triangle distance map shows that the lysozyme molecule is divided into three domains, 1–40, 41–
H, Wakana, H, Yokomizo, H, Wako, Y, Isogai, K, Kosuge, N, Saito   +5 more
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On the computation of the tertiary structure of globular proteins

Journal of Theoretical Biology, 1978
Abstract A method is presented to compute the approximate locations of α carbon atoms of proteins using experimentally obtainable information. This information consists of distances between nearest neighbor α carbon atoms, locations of SS bonds, primary sequence of amino acids as reflected by hydrophobic and hydrophylic residues and the assumption ...
M, Ycas, N S, Goel, J W, Jacobsen
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Comparison of homologous tertiary structures of proteins

Journal of Theoretical Biology, 1974
Homology in sequences of proteins which have the same or similar function has been studied as a problem of comparative biochemistry and molecular evolution. It is therefore of interest to examine homology in three-dimensional structures, e.g. whether folding of polypeptides having common residues gives rise to the same tertiary structure or not.
K, Nishikawa, T, Ooi
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Computing tertiary structures of proteins

Journal of Protein Chemistry, 1990
Using only data on sequence, a method of computing a low-resolution tertiary structure of a protein is described. The steps are: (a) Estimate the distances of individual residues from the centroid of the molecule, using data on hydrophobicity and additional geometrical constraints. (b) Using these distances, construct a two-valued matrix whose elements,
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Probing Protein Tertiary Structure with Amidination

Analytical Chemistry, 2005
A chemical derivatization method, amidination, that has recently been effectively employed in peptide mass spectrometry experiments is used to covalently modify lysines in several standard proteins. Protein and peptide mass spectra identify sites at which the reaction does or does not occur.
Dariusz J, Janecki, Richard L, Beardsley, James P, Reilly   +2 more
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Ab initio Tertiary Structure Prediction of Proteins

Journal of Global Optimization, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
John L. Klepeis, Christodoulos A. Floudas   +1 more
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