Results 261 to 270 of about 319,877 (305)

Evolution and the Tertiary Structure of Proteins

Annual Review of Biophysics and Bioengineering, 1984
The fact that biological information is stored in the form of DNA has led some molecular biologists and biophysicists to the view that evolutionary history will be most evident in DNA sequences. This view is attractive, for there is a redundancy in the genetic code, and the number of base changes is a sensitive indicator of evolutionary distances ...
M, Bajaj, T, Blundell
openaire   +2 more sources

Hydrophobic moments of tertiary protein structures

Proteins: Structure, Function, and Bioinformatics, 2003
AbstractThe helical hydrophobic moment is a measure of the amphiphilicity of a segment of protein secondary structure. Such measure yields information of potential relevance for issues relating to cell surface binding and secondary structure function. The present article describes a global analog of the helical hydrophobic moment.
openaire   +2 more sources

Ab initio Tertiary Structure Prediction of Proteins

Journal of Global Optimization, 2003
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Klepeis, J. L., Floudas, C. A.
openaire   +2 more sources

Comparison of homologous tertiary structures of proteins

Journal of Theoretical Biology, 1974
Homology in sequences of proteins which have the same or similar function has been studied as a problem of comparative biochemistry and molecular evolution. It is therefore of interest to examine homology in three-dimensional structures, e.g. whether folding of polypeptides having common residues gives rise to the same tertiary structure or not.
K, Nishikawa, T, Ooi
openaire   +2 more sources

Computational Methods for Protein Tertiary Structure Analysis

2023
Protein folding accuracy is fundamental to all cells. In spite of this, it is difficult to maintain the fidelity of protein synthesis and folding due to the fact that the implicit genetic and biochemical systems are inherently prone to error, which leads to the constant production of a certain amount of misfolded proteins.
openaire   +2 more sources

New Programs for Protein Tertiary Structure Prediction

Nature Biotechnology, 1993
Prediction of protein tertiary structure remains an unsolved problem in molecular biology, but a solution to this problem is extremely important for protein engineering and rational drug design. Recent developments in motif recognition and side chain modeling present the prospect of nearly automatic model building for a large fraction of newly ...
J S, Fetrow, S H, Bryant
openaire   +2 more sources

Protein denaturation and tertiary structure

Journal of Chemical Education, 1986
Students may dutifully learn the concepts of protein structure, but meaning is often abstracted due to the lack of opportunity for observing the physical entity. To bridge this gap, an inexpensive denaturation experiment is designed to demonstrate the presence of tertiary structure.
openaire   +1 more source

The MULTICOM Protein Tertiary Structure Prediction System

2013
With the expansion of genomics and proteomics data aided by the rapid progress of next-generation sequencing technologies, computational prediction of protein three-dimensional structure is an essential part of modern structural genomics initiatives. Prediction of protein structure through understanding of the theories behind protein sequence-structure
Jilong, Li, Debswapna, Bhattacharya, Renzhi, Cao, Badri, Adhikari, Xin, Deng, Jesse, Eickholt, Jianlin, Cheng   +6 more
openaire   +2 more sources

Efficient Approaches for Retrieving Protein Tertiary Structures

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 2012
The 3D conformation of a protein in the space is the main factor which determines its function in living organisms. Due to the huge amount of newly discovered proteins, there is a need for fast and accurate computational methods for retrieving protein structures.
Georgina, Mirceva, Ivana, Cingovska, Zoran, Dimov, Danco, Davcev   +3 more
openaire   +2 more sources

Does secondary structure determine tertiary structure in proteins?

Proteins: Structure, Function, and Bioinformatics, 2005
AbstractIs highly approximate knowledge of a protein's backbone structure sufficient to successfully identify its family, superfamily, and tertiary fold? To explore this question, backbone dihedral angles were extracted from the known three‐dimensional structure of 2,439 proteins and mapped into 36 labeled, 60° × 60° bins, called mesostates. Using this
Haipeng, Gong, George D, Rose
openaire   +2 more sources