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Protein Structure Prediction and Structural Genomics
Science, 2001Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information about a subset of the proteins, computational structure ...
D, Baker, A, Sali
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Journal of the Society of Dyers and Colourists, 1939
THE structure of proteins is the major unsolved problem on the boundary of chemistry and biology to-day. We have not yet found the key to the problem, but in recent years a mass of new evidence and new lines of attack have enabled us to see it in a far more concrete and precise form, and to have some hope that we are near to solving it.
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THE structure of proteins is the major unsolved problem on the boundary of chemistry and biology to-day. We have not yet found the key to the problem, but in recent years a mass of new evidence and new lines of attack have enabled us to see it in a far more concrete and precise form, and to have some hope that we are near to solving it.
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2008
Protein structure prediction has matured over the past few years to the point that even fully automated methods can provide reasonably accurate three-dimensional models of protein structures. However, until now it has not been possible to develop programs able to perform as well as human experts, who are still capable of systematically producing better
AlLazikani B, Hill EE, Morea V
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Protein structure prediction has matured over the past few years to the point that even fully automated methods can provide reasonably accurate three-dimensional models of protein structures. However, until now it has not been possible to develop programs able to perform as well as human experts, who are still capable of systematically producing better
AlLazikani B, Hill EE, Morea V
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2016
This chapter explores the structures of proteins in more detail than thus far in this text. Building on the basic structural and physical chemistry of amino acids and protein conformations, it examines the features that stabilize native states. Proteins combine the unity of a common and repetitive mainchain with the variety available from a sequence of
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This chapter explores the structures of proteins in more detail than thus far in this text. Building on the basic structural and physical chemistry of amino acids and protein conformations, it examines the features that stabilize native states. Proteins combine the unity of a common and repetitive mainchain with the variety available from a sequence of
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The structure of protein evolution and the evolution of protein structure
Current Opinion in Structural Biology, 2008The observed distribution of protein structures can give us important clues about the underlying evolutionary process, imposing important constraints on possible models. The availability of results from an increasing number of genome projects has made the development of these models an active area of research.
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Molecular Biotechnology, 2009
Web-based protein structure databases come in a wide variety of types and levels of information content. Those having the most general interest are the various atlases that describe each experimentally determined protein structure and provide useful links, analyses, and schematic diagrams relating to its 3D structure and biological function.
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Web-based protein structure databases come in a wide variety of types and levels of information content. Those having the most general interest are the various atlases that describe each experimentally determined protein structure and provide useful links, analyses, and schematic diagrams relating to its 3D structure and biological function.
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Deconstructing protein structure
Current Biology, 1991Proteins are responsible for many important cellular functions, and in order to fulfrtl its role, each protein must fold correctly into a unique three-dimensional structure. Three decades of research on a wide variety of proteins have confirmed Anfinsen’s originaI demonstration that the primary ammo acid sequence encodes all the information necessary ...
S, Marqusee, L, Regan
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Current Opinion in Chemical Biology, 2001
The prediction of protein structure, based primarily on sequence and structure homology, has become an increasingly important activity. Homology models have become more accurate and their range of applicability has increased. Progress has come, in part, from the flood of sequence and structure information that has appeared over the past few years, and ...
B, Al-Lazikani +3 more
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The prediction of protein structure, based primarily on sequence and structure homology, has become an increasingly important activity. Homology models have become more accurate and their range of applicability has increased. Progress has come, in part, from the flood of sequence and structure information that has appeared over the past few years, and ...
B, Al-Lazikani +3 more
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Helical Structures in Proteins
Biomacromolecules, 2001We examine a minimal model for helix-forming polymers. The monomer-monomer potential energy is based on the anisotropic potentials seen in proteins and is used in conjunction with a wormlike backbone. We show that the coil-helix transition involves four states.
J P, Kemp, J Z, Chen
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Current Opinion in Biotechnology, 1998
Genome sequencing projects continue to provide a flood of new protein sequences, and prediction methods remain an important means of adding structural information. Recently, there have been advances in secondary structure prediction, which feed, in turn, into improved fold recognition algorithms.
D R, Westhead, J M, Thornton
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Genome sequencing projects continue to provide a flood of new protein sequences, and prediction methods remain an important means of adding structural information. Recently, there have been advances in secondary structure prediction, which feed, in turn, into improved fold recognition algorithms.
D R, Westhead, J M, Thornton
openaire +2 more sources