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2010
The tertiary structure of proteins can reveal information that is hard to detect in a linear sequence. Knowing the tertiary structure is valuable when generating hypothesis and interpreting data. Unfortunately, the gap between the number of known protein sequences and their associated structures is widening.
Lars, Malmström, David R, Goodlett
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The tertiary structure of proteins can reveal information that is hard to detect in a linear sequence. Knowing the tertiary structure is valuable when generating hypothesis and interpreting data. Unfortunately, the gap between the number of known protein sequences and their associated structures is widening.
Lars, Malmström, David R, Goodlett
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Encephalitogenic Protein: Structure
Science, 1969Amino acid sequences of encephalitogenic proteins from bovine cord and rabbit brain are reported. The bovine protein contains 45 residues. The rabbit protein is identical except for two isopolar substitutions, a dipeptide and amino acid deletion. Analysis of this protein and a 140-residue myelin basic protein indicates that the smaller protein is a ...
R F, Kibler +5 more
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2016
This chapter explores the structures of proteins in more detail than thus far in this text. Building on the basic structural and physical chemistry of amino acids and protein conformations, it examines the features that stabilize native states. Proteins combine the unity of a common and repetitive mainchain with the variety available from a sequence of
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This chapter explores the structures of proteins in more detail than thus far in this text. Building on the basic structural and physical chemistry of amino acids and protein conformations, it examines the features that stabilize native states. Proteins combine the unity of a common and repetitive mainchain with the variety available from a sequence of
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Protein structure similarities
Current Opinion in Structural Biology, 2001Comparison of protein structures can reveal distant evolutionary relationships that would not be detected by sequence information alone. This helps to infer functional properties. In recent years, many methods for pairwise protein structure alignment have been proposed and are now available on the World Wide Web.
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Journal of Molecular Biology, 1989
A new method of comparing protein structures is described, based on distance plot analysis. It is relatively insensitive to insertions and deletions in sequence and is tolerant of the displacement of equivalent substructures between the two molecules being compared.
W R, Taylor, C A, Orengo
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A new method of comparing protein structures is described, based on distance plot analysis. It is relatively insensitive to insertions and deletions in sequence and is tolerant of the displacement of equivalent substructures between the two molecules being compared.
W R, Taylor, C A, Orengo
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Biochimie, 1990
Current methods developed for predicting protein structure are reviewed. The most widely used algorithms of Chou and Fasman and Garnier et al for predicting secondary structure are compared to the most recent ones including sequence similarity methods, neural network, pattern recognition or joint prediction methods.
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Current methods developed for predicting protein structure are reviewed. The most widely used algorithms of Chou and Fasman and Garnier et al for predicting secondary structure are compared to the most recent ones including sequence similarity methods, neural network, pattern recognition or joint prediction methods.
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Protein Structure Prediction and Structural Genomics
Science, 2001Genome sequencing projects are producing linear amino acid sequences, but full understanding of the biological role of these proteins will require knowledge of their structure and function. Although experimental structure determination methods are providing high-resolution structure information about a subset of the proteins, computational structure ...
D, Baker, A, Sali
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Journal of the Society of Dyers and Colourists, 1939
THE structure of proteins is the major unsolved problem on the boundary of chemistry and biology to-day. We have not yet found the key to the problem, but in recent years a mass of new evidence and new lines of attack have enabled us to see it in a far more concrete and precise form, and to have some hope that we are near to solving it.
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THE structure of proteins is the major unsolved problem on the boundary of chemistry and biology to-day. We have not yet found the key to the problem, but in recent years a mass of new evidence and new lines of attack have enabled us to see it in a far more concrete and precise form, and to have some hope that we are near to solving it.
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Protein Structures: Relaxation Matrix Refinement
2007The sections in this article are 1 Introduction 2 The Nuclear Overhauser Effect 3 Structure Calculations 4 Quality of the Structures 5 Application: The ARC Repressor 6 Conclusion 7 Biographical Sketches Related ...
Bonvin, Alexandre M.J.J. +2 more
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1991
The structural comparison of copper-containing proteins has provided a new dimension to the relationships suggested by sequence similarities. Ryden (1988) summarized the putative relationships, suggesting that a primordial single-domain cupredoxin evolved into the multidomain copper oxidases.
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The structural comparison of copper-containing proteins has provided a new dimension to the relationships suggested by sequence similarities. Ryden (1988) summarized the putative relationships, suggesting that a primordial single-domain cupredoxin evolved into the multidomain copper oxidases.
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