The SCOP database in 2020: expanded classification of representative family and superfamily domains of known protein structures [PDF]
, 2019 Antonina Andreeva +3 more
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The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability [PDF]
, 2015 A.T. Gres +5 more
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The effects of AdipoRon on cytochrome P450-related gene expression, acute steroidogenic regulatory protein, and structure of ovary in polycystic ovary syndrome model [PDF]
, 2023 Pegah Hazrati +4 more
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FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Structural and Mechanistic Analysis of the Slx1-Slx4 Endonuclease
Cell Reports, 2015 The SLX1-SLX4 endonuclease required for homologous recombination and DNA repair in eukaryotic cells cleaves a variety of branched DNA structures. The nuclease subunit SLX1 is activated by association with a scaffolding protein SLX4.
Vineet Gaur +7 more
doaj +1 more source
A reference dataset for the analyses of membrane protein secondary structures and transmembrane residuesusing circular dichroism spectroscopy [PDF]
, 2011 Ali Abdul-Gader +2 more
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On the structural complexity of a protein [PDF]
Protein Engineering, Design and Selection, 2003 The determination of the configuration of a protein in three-dimensional (3D) space constitutes one of the major challenges in molecular biology research today. A method consists in choosing a protein structure from a database that minimizes an energy function.
openaire +2 more sources
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
GalaxyRefineComplex: Refinement of protein-protein complex model structures driven by interface repacking [PDF]
, 2016 Lim Heo, Hasup Lee, Chaok Seok
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