Results 61 to 70 of about 12,004,907 (291)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Prediction of protein-protein interaction types using association rule based classification [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Park et alBackground: Protein-protein interactions (PPI) can be classified according to their characteristics into, for example obligate or transient ...
José A Reyes, Kim, JW, Kim, S, Kim Ji, Sangsoo Kim, Gilbert, D, Park, SH, Reyes José A, Reyes, JA, Kim Sangsoo, Park Sung, Ji Kim, David R Gilbert, Gilbert David R, Sung Park   +14 more
core   +1 more source

De novo design of protein minibinder agonists of TLR3

Nature Communications
Toll-like Receptor 3 (TLR3) is a pattern recognition receptor that initiates antiviral immune responses upon binding double-stranded RNA (dsRNA). Several nucleic acid-based TLR3 agonists have been explored clinically as vaccine adjuvants in cancer and ...
Chloe S. Adams, Hyojin Kim, Abigail E. Burtner, Dong Sun Lee, Craig Dobbins, Cameron Criswell, Brian Coventry, Adri Tran-Pearson, Ho Min Kim, Neil P. King   +9 more
doaj   +1 more source

blkn, a novel Medicago truncatula mutant achieving black nodule phenotype

Highlights in BioScience, 2020
blkn is a Medicago truncatula mutant that is achieving null function-black nodule phenotype. blkn is a Tnt1-retrotransposon mutant, Tnt1 is Nicotiana tabacum retro-transposon which is replicated via RNA copy and integrated in plant genome. Interestingly,
Asmaa Hassan, Naglaa Abdallah, Mohamed A-bouzeid, Ghada Abu El-Heba   +3 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural snapshots of the mechanism of ATP-dependent DNA damage recognition by UvrA

Nature Communications
Nucleotide excision repair is a DNA repair pathway which detects and fixes various DNA lesions that distort the structure of DNA. In bacteria, the pathway starts with the UvrA protein which has two adenosine triphosphatase modules and forms dimers.
Shivlee Nirwal, Mariusz Czarnocki-Cieciura, Weronika Zajko, Krzysztof Skowronek, Roman H. Szczepanowski, Marcin Nowotny   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Mutational analysis of the AtNUDT7 Nudix hydrolase from Arabidopsis thaliana reveals residues required for protein quaternary structure formation and activity. [PDF]

, 2009
Arabidopsis thaliana AtNUDT7, a homodimeric Nudix hydrolase active on ADP-ribose and NADH, exerts negative control on the major signaling complex involved in plant defense activation and programmed cell death.
Goch, Grażyna, Olejnik, Kamil, Grynberg, Marcin, Basińska, Teresa, Kraszewska, Elzbieta, Gruszecki, Wiesław I, Plochocka, Danuta   +6 more
core   +1 more source

Polyphosphate and tyrosine phosphorylation in the N-terminal domain of the human mitochondrial Lon protease disrupts its functions

Scientific Reports
Phosphorylation plays a crucial role in the regulation of many fundamental cellular processes. Phosphorylation levels are increased in many cancer cells where they may promote changes in mitochondrial homeostasis.
Nina Kunová, Gabriela Ondrovičová, Jacob A. Bauer, Veronika Krajčovičová, Matyáš Pinkas, Barbora Stojkovičová, Henrieta Havalová, Veronika Lukáčová, Lenka Kohútová, Július Košťan, Lucia Martináková, Peter Baráth, Jiří Nováček, Sebastian Zoll, Sami Kereïche, Eva Kutejová, Vladimír Pevala   +16 more
doaj   +1 more source

Arp2/3 Inhibition Synergizes With PARP Inhibitors by Impairing Homologous Recombination in Gastric Cancer Cells

Frontiers in Bioscience-Landmark
Background:Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown limited efficacy in gastric cancer, primarily due to the rarity of inherent homologous recombination (HR) deficiency.
Wenlong Li, Xinyue Pei, Yongpei Li, Yanji Lu, Xian Hong, Ming Sui, Qiang Li, Xueying Sun, Jingqiu Wang, Enming Zhang, Yihan Liu, Tao Wang, Jing Xu, Zhihui Deng   +13 more
doaj   +1 more source